지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 921 - 934 (14page)
이용수
초록· 키워드
오류제보하기
Lck-interacting transmembrane adaptor 1 (LIME) has been previously identified as a raft-associated transmembrane protein expressed predominantly in T and B lymphocytes. Although LIME is shown to transduce the immunoreceptor signaling and immunological synapse formation via its tyrosine phosphorylation by Lck, a Src-family kinase, the in vivo function of LIME has remained elusive in the previous studies. Here we report that LIME is preferentially expressed in effector T cells and mediates chemokine-mediated T cell migration. Interestingly, in LIME-/- mice, while T cell receptor stimulation-dependent proliferation, differentiation to effector T cells, cytotoxic T lymphocyte (CTL) function and regulatory T lymphocyte (Treg) function were normal, only T cell-mediated inflammatory response was significantly defective. The reduced inflammation was accompanied by the impaired infiltration of leukocytes and T cells to the inflammatory sites of LIME-/- mice. More specifically, the absence of LIME in effector T cells resulted in the reduced migration and defective morphological polarization in response to inflammatory chemokines such as CCL5 and CXCL10. Consistently, LIME-/- effector T cells were found to be defective in chemokine-mediated activation of Rac1 and Rap1, and dysregulated phosphorylation of Pyk2 and Cas. Taken together, the present findings show that LIME is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Ahn, E. / 2006 / LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation / Blood 107:1521~1527
Bonecchi, R. / 1998 / Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells(Th1s)and Th2s / J. Exp. Med 187:129~134
Brdicka, T. / 1998 / T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains / Biochem. Biophys. Res. Commun 248:356~360
Brdickova, N. / 2003 / LIME : a new membrane Raft-associated adaptor protein involved in CD4 and CD8coreceptor signaling / J. Exp. Med 198:1453~1462
Cher, D. J. / 1987 / Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones / J. Immunol 138:3688~3694
Bonecchi, R. / 1998 / Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells(Th1s)and Th2s / J. Exp. Med 187:129~134
Brdicka, T. / 1998 / T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains / Biochem. Biophys. Res. Commun 248:356~360
Brdickova, N. / 2003 / LIME : a new membrane Raft-associated adaptor protein involved in CD4 and CD8coreceptor signaling / J. Exp. Med 198:1453~1462
Cher, D. J. / 1987 / Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones / J. Immunol 138:3688~3694
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Roles of Chemokines in Immune Response to Mycobacterial Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .12
-
국내 석회생산 산업공정부문 온실가스 배출계수 개발
한국기후변화학회지
2020 .10
-
Arbuscular Mycorrhizal Fungal Communities in the Roots of Maize Lines Contrasting for Al Tolerance Grown in Limed and Non-Limed Brazilian Oxisoil
Journal of Microbiology and Biotechnology
2015 .01
-
Determination of traces of organic additives in traditional lime mortars : A preliminary study
한국분석과학회 학술대회
2017 .11
-
Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .03
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
Immune Modulatory Effects of Mesenchymal Stem Cells Mediated by Lymphocyte Recruitment
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .06
-
An experimental study of material characteristics of lime mortars used for Namhansanseong Yeojang
한국분석과학회 학술대회
2017 .11
-
Proteomic Analysis of Shigella Virulence Effectors Secreted under Different Conditions
Journal of Microbiology and Biotechnology
2017 .01
-
Segmented Filamentous Bacteria Induce Divergent Populations of Antigen-Specific CD4 T Cells in the Small Intestine
Molecules and Cells
2019 .01
-
Compound K attenuates stromal cell-derived growth factor 1 (SDF-1)-induced migration of C6 glioma cells
Nutrition Research and Practice
2016 .06
-
Compound K attenuates stromal cell-derived growth factor 1 (SDF-1)-induced migration of C6 glioma cells
Nutrition Research and Practice
2016 .06
-
Endogenously Synthesized n-3 fatty Acids in fat-1 Transgenic Mice Suppresses B Cell Activation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .12
-
Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
Molecules and Cells
2021 .01
-
Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases
Molecules and Cells
2023 .02
-
공극 규모에서의 초임계상 이산화탄소 거동 가시화를 위한 마이크로모델의 개발과 적용
대한지질학회 학술대회
2015 .10
-
부여 능산리 서고 분군 1·2호분 내벽의 과학적 조사를 통한 벽화 존재 유무 연구
박물관 보존과학
2019 .11
-
Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells
Genes & Genomics
2021 .08
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
The Role of Lymphatic Niches in T Cell Differentiation
Molecules and Cells
2016 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0