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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 366 - 372 (7page)
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Since, side effects of antibiotics are frequently emphasized these days, their use is gradually diminishing, and alternative drugs are being developed. We have sought to reintroduce them as raw materials for human health as conventional ‘weapons’ that have been retired after their historical duties. In this study, we investigated the anti-inflammatory effects of lincomycin (LIN), on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Our findings show that LIN potently inhibited production of LPS-induced proinflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), without cytotoxicity. Consistent with these findings, LIN strongly decreased protein expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX-2). Furthermore, LIN reduced pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. To further elucidate the mechanisms of these inhibitory effects of LIN, we studied LPS-induced IκB-α degradation, and mitogen-activated protein kinase (MAPK) phosphorylation. LIN suppressed downregulation of inhibitory κB (IκB-α) degradation, and the phosphorylation of the c-Jun N-terminal kinase (JNK) pathway. Based on these results, we suggest that LIN may be considered a potential candidate as an anti-inflammatory cosmetic or a medicine for human health.
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참고문헌 (27)
참고문헌 신청
Udommethaporn S / 2016 / Assessment of anti-TNF-α activities in keratinocytes expressing inducible TNF-α : A novel tool for anti-TNF-αdrug screening / PLoS One 11:e0159151
Lapara NJ 3rd / 2010 / Suppression of LPS-induced inflammatory responses in acrophages infected with Leishmania / J. Inflamm(Lond) 7:8
Zhang X / 2016 / Methane limit LPS-induced NF-κB/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K/AKT/GSK-3β-mediated IL-10 expression / Sci. Rep 11:6
Gao HM / 2003 / Novel anti-inflammatory therapy for Parkinson's disease / Trends Pharmacol. Sci 24:395~401
Copeland S / 2005 / Acute inflammatory response to endotoxin in mice and humans / Clin. Diagn. Lab. Immunol 12:60~67
Lapara NJ 3rd / 2010 / Suppression of LPS-induced inflammatory responses in acrophages infected with Leishmania / J. Inflamm(Lond) 7:8
Zhang X / 2016 / Methane limit LPS-induced NF-κB/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K/AKT/GSK-3β-mediated IL-10 expression / Sci. Rep 11:6
Gao HM / 2003 / Novel anti-inflammatory therapy for Parkinson's disease / Trends Pharmacol. Sci 24:395~401
Copeland S / 2005 / Acute inflammatory response to endotoxin in mice and humans / Clin. Diagn. Lab. Immunol 12:60~67
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