개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제10호
- 발행연도
- 2020.1
- 수록면
- 1,543 - 1,551 (9page)
이용수
초록· 키워드
오류제보하기
Panax ginseng has a wide range of activities including a neuroprotective effect, skin protective effects, enhanced DNA repairing, anti-diabetic activity, and protective effects against vascular inflammation. In the present study, we sought to discover the inhibitory effects of a mixture of natural products containing Panax ginseng, Ziziphus jujube, Rubi fructus, Artemisiae asiaticae and Scutellaria baicalensis (PZRAS) on osteoclastogenesis and bone remodeling, as neither the effects of a mixture containing Panax ginseng extract, nor its molecular mechanism on bone inflammation, have been clarified yet. PZRAS upregulated the levels of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GSH-R) and glutathione peroxidase (GSH-Px) and reduced malondialdehyde (MDA) in LPS-treated RAW264.7 cells. Moreover, treatment with PZRAS decreased the production of IL-1β and TNF-α. PZRAS also inhibited osteoclast differentiation through inhibiting osteoclastspecific genes like MMP-2, 9, cathepsin K, and TRAP in RANKL-treated RAW264.7 cells. Additionally, PZRAS has inhibitory functions on the RANKL-stimulated activation of ERK and JNK, which lead to a decrease in the expression of NFATc1 and c-Fos. In an in vivo study, bone resorption induced by LPS was recovered by treatment with PZRAS in bone volume per tissue volume (BV/TV) compared to control. Furthermore, the ratio of eroded bone surface of femurs was significantly increased in LPStreated mice compared to vehicle group, but this ratio was significantly reversed in PZRAS-treated mice. These results suggest that PZRAS could prevent or treat disorders with abnormal bone loss.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Ralston SH / 2006 / Genetic regulation of bone mass and susceptibility to osteoporosis / Genes Dev 20:2492~2506
McGreevy C / 2011 / Safety of drugs used in the treatment of osteoporosis / Ther. Adv. Drug Saf 2:159~172
O'Regan RM / 2001 / Selective estrogen-receptor modulators in 2001 / Oncology(Williston Park, NY) 15:1177~1185
Rejnmark L / 2011 / New and emerging antiresorptive treatments in osteoporosis / Curr. Drug Saf 6:75~88
Khosla S / 2008 / Building bone to reverse osteoporosis and repair fractures / J. Clin. Invest 118:421~428
McGreevy C / 2011 / Safety of drugs used in the treatment of osteoporosis / Ther. Adv. Drug Saf 2:159~172
O'Regan RM / 2001 / Selective estrogen-receptor modulators in 2001 / Oncology(Williston Park, NY) 15:1177~1185
Rejnmark L / 2011 / New and emerging antiresorptive treatments in osteoporosis / Curr. Drug Saf 6:75~88
Khosla S / 2008 / Building bone to reverse osteoporosis and repair fractures / J. Clin. Invest 118:421~428
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway
Molecules and Cells
2022 .10
-
Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
Molecules and Cells
2018 .03
-
The Inactivation of ERK1/2, p38 and NF-kB Is Involved in the Down-Regulation of Osteoclastogenesis and Function by A2B Adenosine Receptor Stimulation
Molecules and Cells
2017 .10
-
Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity
Molecules and Cells
2016 .04
-
Bone Changes in Femoral Bone of Mice Using Calcein Labeling
대한임상검사과학회지
2016 .01
-
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
Molecules and Cells
2015 .01
-
여성건강 관련 특성이 골밀도 이상에 미치는 영향요인: 제5기 2010년 2011년 국민건강영양조사를 이용하여
Journal of The Korean Data Analysis Society
2018 .01
-
Effects of Scytosiphon lomentaria on osteoblastic proliferation and differentiation of MC3T3-E1 cells
Nutrition Research and Practice
2016 .04
-
Effects of Scytosiphon lomentaria on osteoblastic proliferation and differentiation of MC3T3-E1 cells
Nutrition Research and Practice
2016 .04
-
ST5 Positively Regulates Osteoclastogenesis via Src/Syk/calcium Signaling Pathways
Molecules and Cells
2019 .01
-
Antimicrobial agents, outer membrane assembly machine, lipoprotein, lipopolysaccharide, outer membrane β-barrel protein, phospholipid
Journal of Microbiology and Biotechnology
2019 .01
-
갈색거저리 유충 에탄올 추출물이 RANKL에 의해 유도되는 파골세포 분화에 미치는 영향
생명과학회지
2020 .11
-
RANKL 유도된 파골세포 분화에 대한 풀무치 에탄올 추출물의 분화 억제 효과
생명과학회지
2019 .10
-
Inhibitory Effects of Curcuma xanthorrhiza Supercritical Extract and Xanthorrhizol on LPS-Induced Inflammation in HGF-1 Cells and RANKL-Induced Osteoclastogenesis in RAW264.7 Cells
Journal of Microbiology and Biotechnology
2018 .01
-
Augmented Osteoclastogenesis from Committed Osteoclast Precursors by Periodontopathic Bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis
한국미생물·생명공학회지
2016 .12
-
Inhibitory Effects of Boesenbergia pandurata on Age-Related Periodontal Inflammation and Alveolar Bone Loss in Fischer 344 Rats
Journal of Microbiology and Biotechnology
2018 .01
-
Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro
Journal of Microbiology and Biotechnology
2018 .01
-
Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
Molecules and Cells
2019 .01
-
Bee Venom Decreases LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells
Journal of Microbiology and Biotechnology
2017 .01
-
Simultaneous Quantification of 13 Ginsenosides by LC-MS/MS and its Application in Diverse Ginseng Extracts
Mass Spectrometry Letters
2018 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0