지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제4호
- 발행연도
- 2021.1
- 수록면
- 621 - 629 (9page)
이용수
초록· 키워드
오류제보하기
Shigella flexneri is a facultative intracellular pathogen that causes bacillary dysentery in humans. Infection with S. flexneri can result in more than a million deaths yearly and most of the victims are children in developing countries. Therefore, identifying novel and unique drug targets against this pathogen is instrumental to overcome the problem of drug resistance to the antibiotics given to patients as the current therapy. In this study, a comparative analysis of the metabolic pathways of the host and pathogen was performed to identify this pathogen’s essential enzymes for the survival and propose potential drug targets. First, we extracted the metabolic pathways of the host, Homo sapiens, and pathogen, S. flexneri, from the KEGG database. Next, we manually compared the pathways to categorize those that were exclusive to the pathogen. Further, all enzymes for the 26 unique pathways were extracted and submitted to the Geptop tool to identify essential enzymes for further screening in determining the feasibility of the therapeutic targets that were predicted and analyzed using PPI network analysis, subcellular localization, druggability testing, gene ontology and epitope mapping. Using these various criteria, we narrowed it down to prioritize 5 novel drug targets against S. flexneri and one vaccine drug targets against all strains of Shigella. Hence, we suggest the identified enzymes as the best putative drug targets for the effective treatment of S. flexneri.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Functional Prediction of Hypothetical Proteins from Shigella flexneri and Validation of the Predicted Models by Using ROC Curve Analysis
Genomics & informatics
2018 .01
-
Host Cell Nuclear Localization of Shigella flexneri Effector OspF Is Facilitated by SUMOylation
Journal of Microbiology and Biotechnology
2017 .01
-
Erratum to “Analysis of potential drug-drug interactions in the intensive care unit using healthcare claims database and drug information database”
한국데이터정보과학회지
2019 .01
-
Single-molecule FRET–based approach for protein-targeted drug discovery
Molecules and Cells
2024 .01
-
Proteomic Analysis of Shigella Virulence Effectors Secreted under Different Conditions
Journal of Microbiology and Biotechnology
2017 .01
-
Strategies to Isolate Drug-resistant Strains and to Identify New Drug Resistance Mechanisms
한국미생물학회 학술대회논문집
2022 .10
-
Genetic mutations affecting mitochondrial function in cancer drug resistance
Genes & Genomics
2023 .03
-
Advancements in Antiviral Drug Development: Comprehensive Insights into Design Strategies and Mechanisms Targeting Key Viral Proteins
Journal of Microbiology and Biotechnology
2024 .07
-
Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis
Genes & Genomics
2021 .01
-
Microbial Metabolite in Metabolic Diseases and Drug Responses
한국미생물학회 학술대회논문집
2021 .08
-
Impact of UV-C Irradiation on Bacterial Disinfection in a Drinking Water Purification System
Journal of Microbiology and Biotechnology
2023 .01
-
Drug Repositioning for Selective Antibacterials against Bacterial Pathogens
한국미생물학회 학술대회논문집
2015 .04
-
Intestinal Organoid as a Research Platform for the Virus-host Interaction
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2023 .06
-
Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway
Journal of Microbiology and Biotechnology
2023 .01
-
Identifying of common metabolic changes following various drug regimens for major depressive disorder
한국분석과학회 학술대회
2024 .11
-
CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures
Molecules and Cells
2019 .01
-
Quality management strategies for drug development
한국분석과학회 학술대회
2016 .11
-
An Improved Approach to Identify Bacterial Pathogens to Human in Environmental Metagenome
Journal of Microbiology and Biotechnology
2020 .01
-
Identification of drug target candidates of the swine pathogen Actinobacillus pleuropneumoniae by construction of protein–protein interaction network
Genes & Genomics
2018 .01
-
국내외 사례분석을 통한 한국의 장기 온실가스 감축경로 설정 방안 고찰
한국기후변화학회지
2025 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0