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자료유형
학술저널
저자정보
Zhang Chijian (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. ChinaGuangdong He Ji Biotech Co. Ltd. Guan) Lu Yongjie (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. ChinaGuangdong He Ji Biotech Co. Ltd. Guan) Ai Yong (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. ChinaGuangdong He Ji Biotech Co. Ltd. Guan) Xu Xian (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. China) Zhu Siyang (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. China) Zhang Bing (Guangdong He Ji Biotech Co. Ltd. Guangzhou 510000 P.R. China) Tang Minghui (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. China) Zhang Lanyue (School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou 51000) He Tinggang (Hua An Tang Biotech Group Co. Ltd. Guangzhou 510000 P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제4호
발행연도
2021.1
수록면
630 - 636 (7page)

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Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.

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