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논문 기본 정보

자료유형
학술저널
저자정보
Ji Fengcun (Department of General Surgery Sunshine Union Hospital High-Tech District Weifang 261000 P.R. China) Lang Chao (Department of General Surgery Sunshine Union Hospital High-Tech District Weifang 261000 P.R. China) Gao Pengfei (Department of General Surgery Sunshine Union Hospital High-Tech District Weifang 261000 P.R. China) Sun Huanle (Department of General Surgery Sunshine Union Hospital High-Tech District Weifang 261000 P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제6호
발행연도
2021.1
수록면
784 - 793 (10page)

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Previous studies have uncovered the role of circ_0000144 in various tumors. Here, we investigated the function and mechanism of circ_0000144 in gastric cancer (GC) progression. The expression of circ_0000144 in GC tissues and cells was detected through quantitative real-time polymerase chain reaction (qRT-PCR) method. Gain- and loss-of-function experiments including colony formation, wound healing and transwell assays were performed to examine the role of circ_0000144 in GC cells. Furthermore, western blot was conducted to determine the expressions of epithelial mesenchymal transition (EMT)-related proteins. The interaction between circ_0000144 and miR-217 was analyzed by bioinformatic analysis and luciferase reporter assays. The circ_0000144 expression was obviously upregulated in GC tissues and cells. Silencing of circ_0000144 inhibited cell proliferation, migration and invasion of GC cells, but ectopic expression of circ_0000144 showed the opposite results. Moreover, circ_0000144 sponged miR-217, and rescue assays revealed that silencing miR-217 expression reversed the inhibitory effect of circ_0000144 knockdown on the progress of GC. Our findings reveal that circ_0000144 inhibition suppresses GC cell proliferation, migration and invasion via absorbing miR-217, providing a new biomarker and potential therapeutic target for treatment of GC

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