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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 303 - 309 (7page)
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Background: As indoor activity increases with modern lifestyles changes, reduced exposure to sunlight may lead to reduced vitamin D synthesis. Previous studies demonstrated that increased vitamin D level is associated with decreased risk of colon cancer; therefore, this study attempted to determine the association between vitamin D and colon polyps, which may be precancerous lesions, in participants who underwent colonoscopy exams. Methods: A total of 31,004 participants who underwent routine health checkups, including vitamin D level and colonoscopy, at Samsung Medical Center in South Korea from 2010 to 2018 were included in the study. Colorectal polyps were diagnosed through biopsy after performing colonoscopy exams. Participants were categorized into three groups according to level of vitamin D (deficient: <20 ng/mL), insufficient: 20≤ vitamin D <30 ng/mL, and sufficient: ≥30 ng/mL). We analyzed the presence of colorectal polyps according to vitamin D level, and performed multiple logistic regression analyses for the association between vitamin D level and colorectal polyps. Results: About 50% of participants had colorectal polyps (hyperplastic polyp, n=4,864; adenomatous polyp, n=10,470; adenocarcinoma, n=24). There were no significant associations between vitamin D categories and colorectal polyp and colorectal cancer. However, when further analyzing by type of polyp, the risk of hyperplastic polyps significantly decreased with increasing vitamin D levels (P for trend=0.006). Conclusion: We did not find evidence for an association between vitamin D and overall colorectal polyps; however, we observed a trend for decreased odds of hyperplastic polyps with increased vitamin D levels in comparison to vitamin D deficient subjects.
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참고문헌 (3)
참고문헌 신청
나은희 / 2015 / 한국인에서 비타민 D: 성별, 연령, 거주지, 계절에 따른 상태 및 결핍의 유병률 / Laboratory Medicine Online 5(2):84~91
Morimoto LM / 2002 / Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? / Cancer Epidemiol Biomarkers Prev 11(10 Pt 1):1012~1018
Bryce C / 2018 / Association of 25-OH vitamin D status with findings on screening colonoscopy / Mil Med 183(suppl_1):547~551
Morimoto LM / 2002 / Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? / Cancer Epidemiol Biomarkers Prev 11(10 Pt 1):1012~1018
Bryce C / 2018 / Association of 25-OH vitamin D status with findings on screening colonoscopy / Mil Med 183(suppl_1):547~551
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