지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 30 - 38 (9page)
이용수
초록· 키워드
오류제보하기
Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata . However, the biological functions of CD in human metabolism have been rarely reported until now. Autophagy is the self-degradation process related to cancer cell metastasis. Here, we elucidated the effects of CD on human oral squamous cell carcinoma (OSCC) cells’ metastatic ability. We confirmed that CD effectively decreased the proliferation and viability of SCC25 human OSCC cells in time- and dose-dependent manners. Also, the metastasis phenotype of the SCC25 cell (migration, invasion, and epithelial?mesenchymal transition [EMT]) was inhibited by CD. To further investigate the mechanism by which CD inhibited the metastatic capacity, we detected the relationship between EMT and autophagy in the SCC25 cells. The results revealed that CD inhibited the metastasis of the SCC25 cells by attenuating autophagy. Thus, our findings produced a potential novel agent for the treatment of human OSCC metastasis.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Wang Y / 2019 / Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells / Autophagy 15:886~899
Zhang Y / 2018 / Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway / Cancer Sci 109:3865~3873
Wei R / 2019 / FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis / J Exp Clin Cancer Res 38:112
White E / 2012 / Deconvoluting the context-dependent role for autophagy in cancer / Nat Rev Cancer 12:401~410
Datta S / 2019 / Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway / Apoptosis 24:414~433
Zhang Y / 2018 / Thymoquinone inhibits the metastasis of renal cell cancer cells by inducing autophagy via AMPK/mTOR signaling pathway / Cancer Sci 109:3865~3873
Wei R / 2019 / FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis / J Exp Clin Cancer Res 38:112
White E / 2012 / Deconvoluting the context-dependent role for autophagy in cancer / Nat Rev Cancer 12:401~410
Datta S / 2019 / Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway / Apoptosis 24:414~433
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Immune Network
2023 .10
-
CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy
Immune Network
2023 .08
-
Autophagy: a lysosomal degradation process for cellular homeostasis and its relationship with oral squamous cell carcinoma
International Journal of Oral Biology
2021 .01
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
Antitumor effect of E7080 in oral carcinoma xenograft model
Oral Biology Research
2016 .01
-
Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
Immune Network
2019 .06
-
Synchronous Occurrence of Primary Cutaneous Anaplastic Large Cell Lymphoma and Squamous Cell Carcinoma
Annals of Dermatology
2016 .01
-
T-Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity
Cancer Research and Treatment
2020 .01
-
Early Growth Response Protein-1 Involves in Transforming Growth factor-β1 Induced Epithelial-Mesenchymal Transition and Inhibits Migration of Non-Small-Cell Lung Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues
Immune Network
2016 .04
-
Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Immune Network
2020 .02
-
Potential Role of S100A8 in Cutaneous Squamous Cell Carcinoma Differentiation
Annals of Dermatology
2016 .01
-
Lipopeptides Extract from Bacillus Amyloliquefaciens Induce Human Oral Squamous Cancer Cell Death
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma
The Korean Journal of Physiology & Pharmacology
2024 .05
-
A Retrospective Clinical View of Basal Cell Carcinoma and Squamous Cell Carcinoma in the Head and Neck Region: A Single Institution's Experience of 247 Cases over 19 Years
Archives of craniofacial surgery : ACFS
2016 .01
-
Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis
Blood Research
2018 .01
-
CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition
Gut and Liver
2021 .01
-
CD8-dependent Tumor Growth Inhibition by Tumor Cells Genetically Modified with 4-1BBL
대한의생명과학회지
2021 .12
-
Autophagy in Tumorigenesis and Cancer Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of Peripheral Blood CD4 + CD25 + Regulatory T Cell on Postoperative Immunotherapy for Patients with Renal Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0