Role of repeat procalcitonin estimation at 48 hours for outcome in pregnancy associated sepsis: a prospective observational study

Rachna Agarwal; Medha Mohta; Kavita Sharma; Mohit Mehndiratta; Himsweta Srivastava; Almeida Edelbert Anthonio

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자료유형: 학술저널

저자정보: Rachna Agarwal (University College of Medical Sciences & Guru Teg Bahadur Hospital) Medha Mohta (University College of Medical Sciences & Guru Teg Bahadur Hospital) Kavita Sharma (University College of Medical Sciences & Guru Teg Bahadur Hospital) Mohit Mehndiratta (University College of Medical Sciences & Guru Teg Bahadur Hospital) Himsweta Srivastava (University College of Medical Sciences & Guru Teg Bahadur Hospital) Almeida Edelbert Anthonio (University College of Medical Sciences & Guru Teg Bahadur Hospital)

저널정보: 대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제64권 제1호

발행연도: 2021.1

수록면: 27 - 33 (7page)

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ObjectivesWe assessed whether repeat procalcitonin (PCT) estimation has a role in detecting organ dysfunctions and mortality inpregnancy associated sepsis (PAS). MethodsThe study included 85 pregnant, post-abortal, and postpartum women with PAS, diagnosed using the quickSequential Organ Failure Assessment criteria. Median interquartile range PCT levels were documented at admissionand 48 hours later. Statistical comparisons were performed between the groups with non-severe and severe (≥1 organfailure) PAS, and between the survivor and mortality groups. The relationship between PCT and the number of organfailures was also assessed. ResultsMost of the subjects with PAS were young and in the postpartum period (mean age 26 years; postpartum 55%). Sixteen (19%) patients died due to PAS. Sixty-two patients (74%) had severe PAS at presentation. Bacteria wereisolated on culture in 64% of the subjects. PCT levels at admission were higher in patients with severe PAS than inthose who did not have severe PAS. At 48 hours, this difference was significant (P=0.014; severe PAS 2.23 ng/mL vs. non-severe PAS 0.20 ng/mL). Furthermore, the number of organ failures increased at 48 hours. The PCT levels weresignificantly higher in the mortality group than in the survivors’ group at admission (8.31 ng/mL vs. 1.72 ng/mL), andthe difference increased further at 48 hours (9.54 ng/mL vs. 1.37 ng/mL). ConclusionRepeat PCT estimation at 48 hours could complement the clinical findings and enhance the prognostic value for PAS.

#Acute-phase reactant #Pregnancy complications #Infectious #Maternal sepsis #Pregnancy #Sepsis during pregnancy #Sepsis in pregnancy

참고문헌 (22)

참고문헌 신청

Meisner M / 2013 / Current status of procalcitonin in the ICU / Neth J Crit Care 17:4~12

Wacker C / 2013 / Procalcitonin as a diagnostic marker for sepsis : a systematic review and meta-analysis / Lancet Infect Dis 13:426~435

Paccolat C / 2011 / Procalcitonin levels during pregnancy, delivery and postpartum / J Perinat Med 39:679~683

Duckworth S / 2016 / Diagnostic biomarkers in women with suspected preeclampsia in a prospective multicentre study / Obstet Gynecol 128:245~252

Ducarme G / 2018 / Efficacy of serum procalcitonin to predict spontaneous preterm birth in women with threatened preterm labour : a prospective observational study / BMC Pregnancy Childbirth 18:65

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