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논문 기본 정보

자료유형
학술저널
저자정보
Kang Won Lee (Division of Gastroenterology and Hepatology Korea University College of Medicine Seoul Korea) Jae Min Lee (Division of Gastroenterology and Hepatology Korea University College of Medicine Seoul Korea) Hyuk Soon Choi (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Eun Sun Kim (Division of Gastroenterology and Hepatology Korea University College of Medicine Seoul Korea) Bora Keum (Division of Gastroenterology and Hepatology Korea University College of Medicine Seoul Korea) Yeon Seok Seo (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yoon Tae Jeen (Department of Gastroenterology and Hepatology Korea University College of Medicine Seoul Korea) Soon Ho Um (Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointe) Hong Sik Lee (Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointe) Hoon Jai Chun (Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointe) Chang Duck Kim (Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointe) Chi Hyuk Oh (Department of Internal Medicine Kyung Hee University College of Medicine Seoul Korea) Hong Bae Kim (Department of Biosystems and Biomaterials Science and Engineering Seoul National University Seoul K)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제3호
발행연도
2021.1
수록면
413 - 419 (7page)

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초록· 키워드

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Background/Aims: Irreversible electroporation (IRE) is a relatively new ablation method. However, the application of IREablation in the treatment of biliary disease has not been attempted. A minimally invasive approach using endoscopic retrogradecholangiopancreatography (ERCP) can be a novel therapeutic modality for IRE ablation. In this study, we aimed to investigate thefeasibility of endoscopic IRE for the biliary tract using an animal model. Methods: A new catheter-type electrode was developed for endoscopic IRE ablation of the biliary tract. We performed ERCP andendoscopic IRE ablations in the normal common bile duct of Yorkshire pigs. The experimental setting of IRE was 500 V/cm (50pulses, 100-μs length). The animals were sacrificed after 24 hr, and the ablated bile duct was examined. Results: Well-demarcated focal color changes were observed on the mucosa of the common bile duct. The depth of change after IREwas confined to the mucosal and submucosal layers. Apoptotic changes in the bile duct were observed only around the IRE ablationarea. Immunohistochemistry assay showed cell death in the bile duct along the electrode. Conclusions: Endoscopic IRE ablation using ERCP was successfully performed in the common bile duct. It can be a potential optionfor the treatment of biliary tumors.
#Ablation #Bile duct #Endoscopic retrograde cholangiopancreatography #Irreversible electroporation

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참고문헌 (24)

참고문헌 신청
Murakami Y / 2011 / Prognostic factors after surgical resection for intrahepatic, hilar, and distal cholangiocarcinoma / Ann Surg Oncol 18:651~658 google schola Koch C / 2020 / Poor prognosis of advanced cholangiocarcinoma : real-world data from a tertiary referral center / Digestion 101:458~465 google schola Aljiffry M / 2009 / Advances in diagnosis, treatment and palliation of cholangiocarcinoma : 1990-2009 / World J Gastroenterol 15:4240~4262 google schola Wagstaff PG / 2016 / Irreversible electroporation : state of the art / Onco Targets Ther 9:2437~2446 google schola Curley SA / 2004 / Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients / Ann Surg 239:450~458 google schola

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