Bone regeneration and graft material resorption in extraction sockets grafted with bioactive silica-calcium phosphate composite versus non-grafted sockets: clinical, radiographic, and histological findings

Doaa Adel-Khattab; Nermeen S. Afifi; Shaimaa M. Abu el Sadat; Mona N. Aboul-Fotouh; Karim Tarek; Robert A. Horowitz

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자료유형: 학술저널

저자정보: Doaa Adel-Khattab (Ain Shams University Faculty of Dentistry) Nermeen S. Afifi (Ain Shams University Faculty of Dentistry) Shaimaa M. Abu el Sadat (Ain Shams University Faculty of Dentistry) Mona N. Aboul-Fotouh (Ain Shams University Faculty of Dentistry) Karim Tarek (Ain Shams University Faculty of Dentistry) Robert A. Horowitz (The NYU College of Dentistry)

저널정보: 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제50권 제6호

발행연도: 2020.1

수록면: 418 - 434 (17page)

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Purpose: The purpose of the present study was to evaluate the effect of silica-calcium phosphate composite (SCPC) granules on bone regeneration in extraction sockets. Methods: Ten patients were selected for a split-model study. In each patient, bone healing in SCPC-grafted and control ungrafted sockets was analyzed through clinical, radiographic, histomorphometric, and immunohistochemical assessments 6 months postoperatively. Results: A radiographic assessment using cone-beam computed tomography showed minimal ridge dimension changes in SCPC-grafted sockets, with 0.39 mm and 1.79 mm decreases in height and width, respectively. Core bone biopsy samples were obtained 6 months post-extraction during implant placement and analyzed. The average percent areas occupied by mature bone, woven bone, and remnant particles in the SCPC-grafted sockets were 41.3%±12%, 20.1%±9.5%, and 5.3%±4.4%, respectively. The percent areas of mature bone and woven bone formed in the control ungrafted sockets at the same time point were 31%±14% and 24.1%±9.4%, respectively. Histochemical and immunohistochemical analyses showed dense mineralized bundles of type I collagen with high osteopontin expression intensity in the grafted sockets. The newly formed bone was well vascularized, with numerous active osteoblasts, Haversian systems, and osteocytes indicating maturation. In contrast, the new bone in the control ungrafted sockets was immature, rich in type III collagen, and had a low osteocyte density. Conclusions: The resorption of SCPC granules in 6 months was coordinated with better new bone formation than was observed in untreated sockets. SCPC is a resorbable bone graft material that enhances bone formation and maturation through its stimulatory effect on bone cell function. Trial Registration: ClinicalTrials.gov Identifier: NCT03897010

#Alveolar ridge augmentation #Cone beam computed tomography #Histological techniques

참고문헌 (39)

참고문헌 신청

Van der Weijden F / 2009 / Alveolar bone dimensional changes of post-extraction sockets in humans : a systematic review / J Clin Periodontol 36:1048~1058

Chappuis V / 2017 / Clinical relevance of dimensional bone and soft tissue alterations postextraction in esthetic sites / Periodontol 2000 73:73~83

Mecall RA / 1991 / Influence of residual ridge resorption patterns on implant fixture placement and tooth position. 1 / Int J Periodontics Restorative Dent 11:8~23

Darby I / 2009 / Ridge preservation techniques for implant therapy / Int J Oral Maxillofac Implants 24(Suppl):260~271

Beck TM / 2010 / Histologic analysis of healing after tooth extraction with ridge preservation using mineralized human bone allograft / J Periodontol 81:1765~1772

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