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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This study was to evaluate the skin sensitization of potassium hydroxide (KOH) by the guinea pig maximization test. In the preliminary test, the induction and challenge dose of KOH were determined as 1.0 and 0.2%, respectively. Guinea pigs were sensitized with intradermal injection of 0.1ml KOH for 24 h. After 1 week, 1.0% of KOH was treated on the site of injection and 0.2% of KOH was challenged 2 weeks later. The average skin reaction evaluated by erythema and edema on the challenge sites and sensitization rate in the KOH-treatment group at 24 h were 0.0 and 0%, respectively, which are substantially low compared with in the 2,4-dinitrochlorobenzene-treatment group (positive control group) (average skin reaction: 3.0, sensitization rate: 100%) and identical with in the distilled water-treatment group (negative control group), representing a weak sensitizing potential. The average skin reaction and sensitization rate observed at 48 h were 0.0 and 0% in the KOH-treatment group, respectively, and 2.0 and 100% in the positive control group, respectively. It was concluded that 1.0% of KOH classified to Grade I, induced no sensitization when tested in guinea pigs.
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참고문헌 (18)
참고문헌 신청
Alam S / 2018 / Bactericidla efficacy of a quaternary ammonium compound with food additive grade calcium hydroxide toward Salmonella infantis and Escherichia coli on abiotic carriers / J Vet Med Sci 80:1482~1489
Animal and Plant Quarantine Agency / 2016 / Regulations on Toxicity Test for Veterinary Medicinal Products
European Chemical Agency / 2020 / Potassium hydroxide – Key value for chemical safety assessment
Hinton A, Jr / 2006 / Antimicrobial activity of potassium hydroxide and lauric acid against microorganisms associated with poultry processing / J Food Prot 69:1282~1286
Johnson GJ / 1975 / Acute toxicity of cesium and rubidium compounds / Toxicol Appl Pharmacol 32:239~245
Animal and Plant Quarantine Agency / 2016 / Regulations on Toxicity Test for Veterinary Medicinal Products
European Chemical Agency / 2020 / Potassium hydroxide – Key value for chemical safety assessment
Hinton A, Jr / 2006 / Antimicrobial activity of potassium hydroxide and lauric acid against microorganisms associated with poultry processing / J Food Prot 69:1282~1286
Johnson GJ / 1975 / Acute toxicity of cesium and rubidium compounds / Toxicol Appl Pharmacol 32:239~245
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