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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 614 - 623 (10page)
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초록· 키워드
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The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird’s nest (EBN), which improves brain function in patients with Alzheimer’s disease and Parkinson’s disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer’s disease. Also, the effect of a sialic acid NDS on Parkinson’s disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer’s disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson’s disease by preventing neurotoxicity induced by MPTP. Key words: dementia, Alzheimer’s disease, Parkinson’s disease, bird’s nest, N-acetylneuraminic acid
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참고문헌 (42)
참고문헌 신청
Canal N / 1996 / Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer's disease / Clin Pharmacol Ther 60:218~228
Careena S / 2018 / Effect of edible bird’s nest extract on lipopolysaccharide-induced impairment of learning and memory in wistar rats / Evid Based Complementary Altern Med 2018:9318789
Chantler P / 2010 / Swifts: A Guide to the Swifts and Treeswifts of the World / Bloomsbury :150~152
Chiavegatto S / 2000 / A functional role for complex gangliosides : Motor deficits in GM2/GD2 synthase knockout mice / Exp Neurol 166:227~234
Colombo JP / 2003 / Potential effects of supplementation with amino acids, choline or sialic acid on cognitive development in young infants / Acta Paediatr 92:42~46
Careena S / 2018 / Effect of edible bird’s nest extract on lipopolysaccharide-induced impairment of learning and memory in wistar rats / Evid Based Complementary Altern Med 2018:9318789
Chantler P / 2010 / Swifts: A Guide to the Swifts and Treeswifts of the World / Bloomsbury :150~152
Chiavegatto S / 2000 / A functional role for complex gangliosides : Motor deficits in GM2/GD2 synthase knockout mice / Exp Neurol 166:227~234
Colombo JP / 2003 / Potential effects of supplementation with amino acids, choline or sialic acid on cognitive development in young infants / Acta Paediatr 92:42~46
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