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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 430 - 443 (14page)
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초록· 키워드
오류제보하기
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with various metabolic diseases, including type 2 diabetes mellitus. There are no approved drugs for NAFLD, and the only approved treatment option is weight reduction. As insulin resistance plays an important role in the development of NAFLD, many antidiabetic drugs have been evaluated for the treatment of NAFLD. Improvement of liver enzymes has been demonstrated by many anti-diabetic drugs, but histological assessment still remains insufficient. Pioglitazone could become the firstline therapy for T2DM patients with NAFLD, based on evidence of histological improvement in patients with biopsyproven nonalcoholic steatohepatitis (NASH). Liraglutide, another promising alternative, is not yet recommended in patients with NAFLD/NASH due to limited evidence. Therefore, well-designed randomized controlled trials should be performed in the near future to demonstrate if and how anti-diabetic drugs can play a role in the treatment of NAFLD.
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등록된 정보가 없습니다.
참고문헌 (106)
참고문헌 신청
Younossi Z / 2019 / Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates / Clin Gastroenterol Hepatol 17:748~755.e3
Byrne CD / 2015 / NAFLD : a multisystem disease / J Hepatol 62(1 Suppl):S47~S64
김경수 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment / Diabetes and Metabolism Journal 43(2):127~143
이은정 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective / Endocrinology and Metabolism 34(3):226~233
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34:274~285
Byrne CD / 2015 / NAFLD : a multisystem disease / J Hepatol 62(1 Suppl):S47~S64
김경수 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment / Diabetes and Metabolism Journal 43(2):127~143
이은정 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective / Endocrinology and Metabolism 34(3):226~233
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34:274~285
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