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논문 기본 정보

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저자정보
Fotios Dimitriadis (1st Department of Urology School of Medicine Aristotle University of Thessaloniki) Maria Papaioannou (Laboratory of Biological Chemistry School of Medicine Faculty of Health Sciences Aristotle Unive) Ioannis Sokolakis (Institute for the Study of Urologic Diseases Aristotle University of Thessaloniki) Aikaterini Fragou (Institute for the Study of Urologic Diseases Aristotle University of Thessaloniki) Dimitrios Hatzichristou (1st Department of Urology School of Medicine Aristotle University of Thessaloniki) Apostolos Apostolidis (Institute for the Study of Urologic Diseases Aristotle University of Thessaloniki)
저널정보
대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제25권 제1호
발행연도
2021.1
수록면
34 - 41 (8page)

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Purpose: Preclinical data increasingly support an impact of low-intensity extracorporeal shockwave therapy (Li-ESWT) on the bladder. We investigated the molecular effects of Li-ESWT on the bladder of a streptozotocin-induced diabetic rat model. Methods: Fifteen 8-week-old male Wistar rats were randomized into 3 groups: a control group (n=5), a group of diabetic rats without treatment (diabetes mellitus [DM], n=5) and a group of diabetic rats treated with Li-ESWT (DM-ESWT, n=5). A single intraperitoneal dose of streptozotocin (60 mg/kg) was used to induce diabetes. Twenty days after diabetes induction, each rat in the DM-ESWT group received 300 shockwaves with an energy flux density of 0.09 mJ/mm2. Sessions were repeated 3 times/week for 2 weeks, followed by a 2-week washout period. Total RNA from bladder tissue was extracted, cDNA was synthesized, and quantitative real-time polymerase chain reaction was performed to analyze the expression pattern of transient receptor potential vanilloid 1 (Trpv1), interleukin-1β (Il1b), and the muscarinic receptors M1, M2, and M3 (Chrm1, Chrm2, and Chrm3). Results: The expression of Trpv1, Il1b, and Chrm2 genes was significantly different between the 3 groups (P=0.002, P<0.0001, and P=0.011, respectively; 1-way analysis of variance). In the DM group, the expression of all genes was higher than in the control group, but statistical significance was observed only for Trpv1 and Il1b (P=0.002 and P<0.0001, respectively). Li-ESWT significantly reduced the expression of Il1b and Chrm2 (P=0.001 and P=0.011, respectively), whereas a nonsignificant tendency for reduced expression was noted for Trpv1 (P=0.069). Conclusions: The induction of diabetes was associated with increased expression of genes related to mechanosensation, inflammation/ ischemia, and contraction in the rat bladder. Li-ESWT reduced the expression of IL1b, Chrm2, and to a lesser extent Trpv1 toward the control levels, suggesting the therapeutic potential of this treatment modality for diabetic cystopathy.
#Extracorporeal shockwave therapy #Urinary bladder #Diabetes mellitus

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참고문헌 (36)

참고문헌 신청
Sokolakis I / 2019 / The basic science behind low-intensity extracorporeal shockwave therapy for erectile dysfunction : a systematic scoping review of pre-clinical studies / J Sex Med 16:168~194 google schola Sokolakis I / 2019 / Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction : a systematic review and meta-analysis of randomised controlled trials / Int J Impot Res 31:177~194 google schola Chen YT / 2018 / Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat / Am J Transl Res 10:1036~1052 google schola Chuang YC / 2019 / Long-term functional change of cryoinjury-induced detrusor underactivity and effects of extracorporeal shock wave therapy in a rat model / Int Urol Nephrol 51:617~626 google schola Chuang YC / 2018 / Urodynamic and molecular characteristics of detrusor underactivity in a rat cryoinjury model and effects of low energy shock wave therapy / Neurourol Urodyn 37:708~715 google schola

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