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논문 기본 정보

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학술저널
저자정보
Lin Hui (울산대학교) 신은석 (울산대학교) 전은정 (울산대학교) 백영준 (울산과학기술원) Scot Garg (East Lancashire Hospitals NHS Trust) 김태현 (울산대학교) 손창배 (울산대학교) 최병주 (울산대학교) Liu Kun (Peking University Shougang Hospital) Song Lin Yuan (울산대학교) Wang Zhi (Peking University Shougang Hospital) Jiang Hao (Peking University Shougang Hospital) Shi Zhentao (Peking University Shougang Hospital) Tang Qiang (Peking University Shougang Hospital)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제12호
발행연도
2020.1
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1,004 - 1,012 (9page)

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Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with ahigh risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections andsubsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novocoronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) followingDCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vesselfailure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vesselthrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differencesin LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariateanalysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completelyhealed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associatedwith an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

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