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논문 기본 정보

자료유형
학술저널
저자정보
Yoon-Jong Park (Department of Biological Sciences College of Natural Sciences Kangwon National University Chunche) Jae-Min Ryu (Department of Biological Sciences College of Natural Sciences Kangwon National University Chunc) Han-Heom Na (Kangwon National University) Hyun Suk Jung (Kangwon National University) Bokhye Kim (Kangwon Center for System Imaging Kangwon National University Chuncheon Republic of Korea) Jin Sung Park (Korean Pharmacopuncture Institute) Byung-Soo Ahn (Korean Pharmacopuncture Institute) Keun-Cheol Kim (Kangwon National University)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제24권 제2호
발행연도
2021.1
수록면
68 - 75 (8page)

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Objectives: The hair follicle is composed of more than 20 kinds of cells, and mesoderm derived dermal papilla cells and keratinocytes cooperatively contribute hair growth via Wnt/β-catenin signaling pathway. We are to investigate β-catenin expression and regulatory mechanism by CBD in alopecia hair tissues and dermal papilla cells. Methods: We performed structural and anatomical analyses on alopecia patients derived hair tissues using microscopes. Pharmacological effect of CBD was evaluated by β-catenin expression using RT-PCR and immunostaining experiment. Results: Morphological deformation and loss of cell numbers in hair shaft were observed in alopecia hair tissues. IHC experiment showed that loss of β-catenin expression was shown in inner shaft of the alopecia hair tissues, indicating that β-catenin expression is a key regulatory function during alopecia progression. Consistently, β-catenin expression was decreased in testosterone or PMA treated dermal papilla cells, suggesting that those treatments are referred as a model on molecular mechanism of alopecia using dermal papilla cells. RT-PCR and immunostaining experiments showed that β-catenin expression was decreased in RNA level, as well as decreased β-catenin protein might be resulted from ubiquitination. However, CBD treatment has no changes in gene expression including β-catenin, but the decreased β-catenin expression by testosterone or PMA was restored by CBD pretreatment, suggesting that potential regulatory effect on alopecia induction of testosterone and PMA. Conclusion: CBD might have a modulating function on alopecia caused by hormonal or excess of signaling pathway, and be a promising application for on alopecia treatment.

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