지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 1 - 6 (6page)
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Persistent pulmonary hypertension of the newborn (PPHN) is a consequence of the failure of a decrease in the elevated pulmonary vascular resistance after birth. Pulmonary vasodilators, including inhaled nitric oxide (iNO), have been the mainstream of targeted therapy for PPHN, but no drugs have been proven to be effective in preterm infants with PPHN. The fetus remains hemodynamically stable despite lower arterial oxygen tension and pulmonary blood flow as compared to full-term newborns. This adaptation is due to the lower oxygen requirement and high oxygen- carrying capacity of fetal circulation. The immature lungs of preterm infants are more vulnerable to reactive oxygen species, and the response of pulmonary vascular dilatation to blood oxygen tension is blunted in preterm infants. Recently, iNO has been reported to be effective in a selected group of preterm infants, such as those with prolonged preterm rupture of membrane-oligohydramnios-pulmonary hypoplasia sequence. PPHN in preterm infants, along with maximum supportive treatment based on fetal physiology and meticulous assessment of cardiovascular function, is in dire need of new treatment guidelines, including optimal dosing strategies for pulmonary vasodilators.
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참고문헌 (34)
참고문헌 신청
Martinho S / 2020 / Persistent pulmonary hypertension of the newborn : pathophysiological mechanisms and novel therapeutic approaches / Front Pediatr 8:342
Kumar VH / 2007 / Characteristics of pulmonary hypertension in preterm neonates / J Perinatol 27:214~219
Nakanishi H / 2018 / Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study / Arch Dis Child Fetal Neonatal Ed 103:F554~61
Jain A / 2015 / Persistent pulmonary hypertension of the newborn : advances in diagnosis and treatment / Semin Fetal Neonatal Med 20:262~271
Barrington KJ / 2017 / Nitric oxide for respiratory failure in infants born at or near term / Cochrane Database Syst Rev 1:CD000399
Kumar VH / 2007 / Characteristics of pulmonary hypertension in preterm neonates / J Perinatol 27:214~219
Nakanishi H / 2018 / Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study / Arch Dis Child Fetal Neonatal Ed 103:F554~61
Jain A / 2015 / Persistent pulmonary hypertension of the newborn : advances in diagnosis and treatment / Semin Fetal Neonatal Med 20:262~271
Barrington KJ / 2017 / Nitric oxide for respiratory failure in infants born at or near term / Cochrane Database Syst Rev 1:CD000399
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