지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Transmembrane proteins are among the most important targets for drug discovery. Cryo-EM is particularly useful in membrane protein research because crystallization of target proteins is not necessary. The Institute of Membrane Proteins is currently being constructed at POSTECH to utilize this technological development and facilitate membrane protein research in Korea. Several instruments, including two cryo-EMs will be installed at the institute for public use. Facilities necessary for antibody development against transmembrane proteins will also be installed. Experts, who can operate these instruments as well as help other external scientists, have been hired. In addition to supporting external research, the institute will carry out internal research. Fourteen research groups from universities and national laboratories have currently participated in this project. By collaborating with staff scientists at the institute, these research groups will conduct structural analysis of membrane proteins and develop antibody drugs against them.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Campbell, M. G. / 2012 / Movies of ice-embedded particles enhance resolution in electron cryo-microscopy / Structure 20:1823~1828
Fleming, N. / 2018 / How artificial intelligence is changing drug discovery / Nature 557:S55~S57
Forli, S. / 2016 / Computational protein-ligand docking and virtual drug screening with the AutoDock suite / Nat Protoc 11:905~919
García-Nafría, J. / 2020 / Cryo-electron microscopy : moving beyond X-ray crystal structures for drug receptors and drug development / Annu Rev Pharmacol Toxicol 60:51~71
Glaeser, R. M. / 2011 / Precise beam-tilt alignment and collimation are required to minimize the phase error associated with coma in high-resolution cryo-EM / J Struct Biol 174:1~10
Fleming, N. / 2018 / How artificial intelligence is changing drug discovery / Nature 557:S55~S57
Forli, S. / 2016 / Computational protein-ligand docking and virtual drug screening with the AutoDock suite / Nat Protoc 11:905~919
García-Nafría, J. / 2020 / Cryo-electron microscopy : moving beyond X-ray crystal structures for drug receptors and drug development / Annu Rev Pharmacol Toxicol 60:51~71
Glaeser, R. M. / 2011 / Precise beam-tilt alignment and collimation are required to minimize the phase error associated with coma in high-resolution cryo-EM / J Struct Biol 174:1~10
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