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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 539 - 539 (1page)
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This study investigated whether HM-chromanone could improve high glucose-induced blockade of insulin signaling in human HepG2 cells. High glucose of 33 mM significantly increased phosphorylation of IRS-1 and decreased phosphorylation of Akt. The insulin signaling effects on glucose uptake and glycogen synthesis were obstructed by high glucose. But HM-chromanone significantly decreased phosphorylation of IRS-1 Ser307 while increasing phosphorylation of IRS-1 Tyr612 and increased phosphorylation of Akt, which restored the insulin signaling damaged by high glucose. HM-chromanone inc ... 전체 초록 보기
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