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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 392 - 392 (1page)
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이 논문의 연구 히스토리 (3)
2022
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Atorvastatin is a widely used statin drug that prevents cardiovascular disease and treats hyperlipidemia. Its human metabolites are 2-OH and 4-OH atorvastatin, which also show highly inhibiting effects on 3-hydroxy-3-methylglutaryl-CoA reductase activity. Producing the hydroxylated metabolites by enzymes and whole-cell biotransformation is more desirable than chemical synthesis. Here, we have found an enzymatic strategy of P450 enzymes for a highly efficient synthesis of the 4-OH atorvastatin, which is an expensive commercial product, by using bacterial ... 전체 초록 보기
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