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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 405 - 405 (1page)
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De-novo-designed synthetic RNA regulators have been utilized to construct complex RNA-based synthetic gene circuits in living cells. We constructed an RNA-only type 1 incoherent feedforward loop (IFFL) circuit in vivo using these regulators and explored their dynamic behaviors. However, there were no significant timescale differences between direct activation and indirect inhibition, and no pulses were observed in the experiment. These results were confirmed by mathematical modeling and simulation results for a wide range of conditions. To increase the delay of the inhibitory pathway, we introdu ... 전체 초록 보기
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