지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 6 - 10 (5page)
이용수
초록· 키워드
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Objectives: Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF. Methods: This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004e2016. Parameters recorded (in addition to standard dual energy Xray absorptiometry parameters): age, smoking, alcohol, corticosteroids, aromatase inhibitors, Depo- Provera, hormone replacement therapy, rheumatoid arthritis, polymyalgia rheumatica, breast or prostate cancer, coeliac disease, and fracture site. Logistic regression was used to model fracture risk and site, and linear regression for impact of factors on L1e4 and femoral BMD. Factor analyses with polychoric correlation matrices and calculation of Eigenvalues were applied to determine association between fracture sites and associated risk factors. Results: A total of 6053 patients were included, 91.1% female. 2094 had sustained at least one FF. Smoking, alcoholism, increased age, height, and fat mass increased FF risk. Sites analysed: femur, tibia/ fibula, humerus, forearm, ribs, and vertebrae. Alcoholism, and increasing tissue thickness and fat mass significantly increased FF risk. Decreased right femoral and vertebral BMD increased overall FF risk. Conclusions: Our study confirms the effect of certain factors on vertebral BMD, but suggests a differential effect on the upper and lower spine, as well as in the dominant and nondominant hip. Different sites of fracture are associated with different risk factors, the most common sites of fracture being the peripheral long bones and vertebrae.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Briot K / 2015 / Glucocorticoid-induced osteoporosis / RMD Open 1:e000014
Allen CS / 2016 / Bisphosphonates for steroidinduced osteoporosis / Cochrane Database Syst Rev 10:CD001347
Hodsman AB / 2008 / 10-year probability of recurrent fractures following wrist and other osteoporotic fractures in a large clinical cohort : an analysis from the Manitoba Bone Density program / Arch Intern Med 168:2261~2267
Johnell O / 2004 / Fracture risk following an osteoporotic fracture / Osteoporos Int 15:175~179
Gossiel F / 2018 / Bone turnover markers after the menopause : T-score approach / Bone 111:44~48
Allen CS / 2016 / Bisphosphonates for steroidinduced osteoporosis / Cochrane Database Syst Rev 10:CD001347
Hodsman AB / 2008 / 10-year probability of recurrent fractures following wrist and other osteoporotic fractures in a large clinical cohort : an analysis from the Manitoba Bone Density program / Arch Intern Med 168:2261~2267
Johnell O / 2004 / Fracture risk following an osteoporotic fracture / Osteoporos Int 15:175~179
Gossiel F / 2018 / Bone turnover markers after the menopause : T-score approach / Bone 111:44~48
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