Clinical Significance of C-X-C Motif Chemokine Receptor 4 and Integrin αvβ6 Expression in Breast Cancer

Hongshan Huang; Mengci Yuan; Shuang-Ling Wu; Jinling Ba; Xinmiao Yu; Xiaoyun Mao; Feng Jin

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저자정보: Hongshan Huang (Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C) Mengci Yuan (Department of Immunology School of Medicine Nankai University Tianjin China) Shuang-Ling Wu (Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C) Jinling Ba (Department of Breast Thyroid Surgery The Affiliated Zhongshan Hospital of Dalian University Dalian) Xinmiao Yu (Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C) Xiaoyun Mao (Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C) Feng Jin (Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.2

발행연도: 2020.1

수록면: 171 - 181 (11page)

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연구배경

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Purpose: C-X-C motif chemokine receptor 4 (CXCR4) and integrin αvβ6 play important roles in the malignant progression of multiple cancers. However, it remains unclear whether the expression of one or both proteins in breast cancer (BC) is of clinical significance. In this study, we investigated the expression of CXCR4 and integrin αvβ6 in BC tissues and their correlation with clinicopathological characteristics, including survival. Methods: CXCR4 and αvβ6 expression in 111 BC tissues was examined by immunocytochemistry. Correlations between the expression of the 2 proteins and patient clinicopathological characteristic were investigated using the Kaplan–Meier method and the Cox proportional hazards model. Results: CXCR4 and αvβ6 were overexpressed in BC tissue compared with normal breast tissue. Overexpression of both molecules was related to lymph node status (p = 0.013 and p = 0.022, respectively). αvβ6 overexpression was also associated with tumor size (p = 0.044). A positive correlation was detected between the expression of CXCR4 and αvβ6 (r = 0.649, p = 0.001), and co-overexpression of both molecules was associated with tumor size (p = 0.018) and lymph node metastasis (p = 0.015). Kaplan–Meier analysis revealed that overexpression of CXCR4, αvβ6, or both molecules was associated with short overall survival (OS; p < 0.001, p < 0.001, and p = 0.009, respectively) and disease-free survival (DFS; p < 0.001, p = 0.005, and p = 0.019, respectively). Multivariate analysis indicated that lymph node metastasis was an independent prognostic factor for unfavorable OS and DFS (p = 0.002 and p = 0.005, respectively), whereas co-overexpression of CXCR4 and αvβ6 was an independent prognostic factor only for OS (p = 0.043). Conclusion: CXCR4 and αvβ6 may play synergistic roles in the progression of BC, and co-targeting of CXCR4 and αvβ6 could be a potential strategy for the prevention and treatment of BC

#Breast neoplasms #Integrin alphaV #Prognosis #Receptors #CXCR4

참고문헌 (30)

참고문헌 신청

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Breuss JM / 1995 / Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling / J Cell Sci 108:2241~2251

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Hongshan Huang

소속기관 Department of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang C