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논문 기본 정보

자료유형
학술저널
저자정보
백종윤 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of) 최두호 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of) 박원 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of) 김해영 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of) 조원경 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of) 유규상 (Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.6
발행연도
2020.1
수록면
622 - 634 (13page)

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Purpose: This study aimed to evaluate survival outcomes and identify prognostic factors for regional oligo-recurrence in breast cancer patients who received salvage local treatment. Methods: In the breast cancer registry of our institution, 18,790 patients received curative surgery for stage I–III breast cancer between January 1995 and June 2016. Of those patients, only 87 (0.5%)underwent salvage local treatment for isolated nodal recurrence on the axillary lymph nodes (ALNs) (n = 58), supraclavicular lymph nodes (SCNs) (n = 17), or internal mammary lymph nodes (IMNs) (n = 12). Results: The median follow-up duration after regional oligo-recurrence was 49 months (range: 6–194 months). For patients with recurrence of ALN, SCN, or IMN, the 5-year progression-free survival (PFS) and overall survival (OS) rates were 40.0%, 32.1%, and 25.0%, respectively (p = 0.3) and 62.7%, 70.0%, and 58.3%, respectively(p = 0.97). In the multivariable analysis for PFS, age at recurrence ≥ 65 years, disease-free interval < 24 months, non-luminal A subtype, and in-field failure (marginally significant) were found to be risk factors (RFs). However, the location of the tumor was not a significant factor for PFS (p = 0.71). When we stratified patients by the number of RFs, the 5-year PFS rates were 67.5% for patients with ≤ 1 RF and 7.3% for those with > 1 RF (p < 0.01). For patients with ≤ 1 RF, the 5-year PFS rates were 73.5% in the ALN group and 51.1% in the SCN/IMN group (p = 0.09). For patients with > 1 RF, the 5-year PFS rates were 7.3% in the ALN group and 7.1% in the SCN/IMN group (p = 1.00). Conclusion: In breast cancer patients with regional oligo-recurrence, clinical outcomes after salvage treatment were favorable in patients with ≤ 1 R

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