지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective. The total haemolytic complement activity (CH50) assay evaluates the functioning of the complement system. Accumulating evidence indicates that the activation of the complement system plays a critical role in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Therefore, this study aimed to investigate whether CH50 levels at diagnosis could reflect the baseline activity of AAV. Methods. This retrospective study included 101 immunosuppressive drug-naïve patients with AAV. At diagnosis, all patients underwent clinical assessments for disease activity, including measurement of the Birmingham Vasculitis Activity Score (BVAS) and Five Factor Score (FFS), and laboratory evaluations, such as tests for CH50, C3, and C4 levels. The association between CH50 levels and disease activity was determined. Results. The median BVAS and FFS at diagnosis were 12.0 and 1.0, respectively, whereas the median CH50 level was 60.4 U/mL. There was a negative correlation between the CH50 level and BVAS (r=−0.241; p=0.015). A CH50 cut-off value of 62.1 U/mL was used to classify the patients into two groups: patients with CH50 levels ＜62.1 U/mL (low-CH50 group) and those with CH50 levels ≥ 62.1 U/mL (high-CH50 group). The low-CH50 group had a higher proportion of patients with high disease activity, based on the BVAS, than the high-CH50 group (52.5% vs. 23.8%, p=0.004). Additionally, the low-CH50 group exhibited a lower relapse- free survival rate than the high-CH50 group; however, this difference was not statistically significant (p=0.082). Conclusion. Low CH50 levels at diagnosis may reflect high baseline activity of AAV.
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참고문헌 (15)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Jennette JC / 2014 / Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease / Nat Rev Rheumatol 10:463~473
Lamprecht P / 2018 / Pathogenetic and clinical aspects of anti-neutrophil cytoplasmic autoantibody-associated vasculitides / Front Immunol 9:680
Angioi A / 2016 / Diagnosis of complement alternative pathway disorders / Kidney Int 89:278~288
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Jennette JC / 2014 / Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease / Nat Rev Rheumatol 10:463~473
Lamprecht P / 2018 / Pathogenetic and clinical aspects of anti-neutrophil cytoplasmic autoantibody-associated vasculitides / Front Immunol 9:680
Angioi A / 2016 / Diagnosis of complement alternative pathway disorders / Kidney Int 89:278~288
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