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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 10 (10page)
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1/10 Background: Nonalcoholic fatty liver disease (NAFLD) is now considered as a hepatic manifestation of metabolic syndrome and elevated alanine aminotransferase (ALT) is commonly related to NAFLD in the absence of viral hepatitis or alcohol abuse. Previous studies have indicated that elevated ALT is associated with diabetes or metabolic syndrome in adults, but the clinical significance of ALT or NAFLD in pregnancy has not been well determined. The objective of this study was to determine the association between elevated ALT in early pregnancy and the development of gestational diabetes or preeclampsia in late pregnancy. Methods: In this retrospective cohort study, pregnant women who met the following inclusion criteria were included: 1) singleton pregnancy; 2) ALT levels were measured in antenatal outpatient clinic at 4–20 weeks of gestation; 3) patients were screened for gestational diabetes and delivered in Cheil General Hospital and Women's Healthcare Center. Cases with viral hepatitis or other liver diseases were excluded. The early ALT levels were divided into two groups (normal ALT [≤ 95th percentile] and elevated ALT [> 95th percentile]), and the frequency of gestational diabetes and preeclampsia was compared between the two groups of cases. Gestational diabetes was screened and diagnosed by two- step procedure (50 g oral glucose challenge test and 75 g glucose challenge test with World Health Organization [WHO] criteria). Results: A total of 2,322 women met the inclusion criteria. Cases with elevated early ALT levels (> 95th percentile) had a higher risk of subsequent gestational diabetes and preeclampsia (gestational diabetes by WHO criteria, 2.1% in normal ALT vs. 6.5% in elevated ALT, P < 0.01; preeclampsia, 1.0% in normal ALT vs. 4.1% in elevated ALT, P < 0.05). This relationship between elevated ALT and increased risk of gestational diabetes/preeclampsia remained significant after adjustment for maternal age and pre-pregnancy body mass index. Conclusion: Elevated unexplained ALT in early pregnancy is associated with the risk of subsequent development of gestational diabetes and preeclampsia in late pregnancy.
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참고문헌 (39)
참고문헌 신청
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Aliment Pharmacol Ther 34(3):274~285
Hyun Chin Cho / 2016 / Prevalence and Factors Associated with Nonalcoholic Fatty Liver Disease in a Nonobese Korean Population / Gut and Liver 10(1):117~125
Choi SY / 2009 / The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans / Am J Gastroenterol 104(8):1953~1960
Zhang T / 2015 / Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population : a prospective cohort study / Atherosclerosis 240(1):144~148
정주영 / 2019 / Non-Alcoholic Fatty Liver Disease and Its Association with Depression in Korean General Population / Journal of Korean Medical Science 34(30):1~11
Hyun Chin Cho / 2016 / Prevalence and Factors Associated with Nonalcoholic Fatty Liver Disease in a Nonobese Korean Population / Gut and Liver 10(1):117~125
Choi SY / 2009 / The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans / Am J Gastroenterol 104(8):1953~1960
Zhang T / 2015 / Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population : a prospective cohort study / Atherosclerosis 240(1):144~148
정주영 / 2019 / Non-Alcoholic Fatty Liver Disease and Its Association with Depression in Korean General Population / Journal of Korean Medical Science 34(30):1~11
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