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논문 기본 정보

자료유형
학술저널
저자정보
Lim Jeong-Hoon (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Han Man-Hoon (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers) Kim Yong-Jin (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers) Kim Mee-Seon (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers) Jung Hee-Yeon (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Choi Ji-Young (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Cho Jang-Hee (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Kim Chan-Duck (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Kim Yong-Lim (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer) Park Sun-Hee (Division of Nephrology Department of Internal Medicine School of Medicine Kyungpook National Univer)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.30
발행연도
2021.1
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1 - 6 (6page)

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Various coronavirus disease 2019 (COVID-19) vaccines are being developed, which show practical preventive effects. Here, we report a 51-year-old healthy man with nephrotic syndrome secondary to minimal change disease (MCD) after Ad26.COV.2 (Janssen) vaccination. He had no comorbid disease and received Ad26.COV.2 on April 13, 2021. Seven days after vaccination, he developed edema and foamy urine. Edema rapidly aggravated with decreased urine volume. He was admitted to the hospital 28 days after vaccination, and his body weight increased by 21 kg after vaccination. His serum creatinine level was 1.54 mg/ dL, and 24-h urinary protein excretion was 8.6 g/day. Kidney biopsy revealed no abnormality in the glomeruli and interstitium of the cortex and medulla under the light microscope. Electron microscopy revealed diffuse effacement of the podocyte foot processes, thus, he was diagnosed with MCD. High-dose steroid therapy was applied, and his kidney function improved three days after steroid therapy. Three weeks after steroid use, his serum creatinine decreased to 0.95 mg/dL, and spot urine protein-to-creatine decreased to 0.2 g/g. This case highlights the risk of new-onset nephrotic syndrome secondary to MCD after vectored COVID-19 vaccination. Although the pathogenesis is uncertain, clinicians need to be careful about adverse renal effects of COVID-19 vaccines.
#Minimal Change Disease #Nephrotic Syndrome #COVID-19 #Vectored Vaccine

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참고문헌 (9)

참고문헌 신청
Vivarelli M / 2017 / Minimal change disease / Clin J Am Soc Nephrol 12(2):332~345 google schola Lebedev L / 2021 / Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine / Am J Kidney Dis 78(1):142~145 google schola D'Agati VD / 2021 / Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine / Kidney Int 100(2):461~463 google schola Holzworth A / 2021 / Minimal change disease following the Moderna mRNA-1273 SARS-CoV-2 vaccine / Kidney Int 100(2):463~464 google schola Weijers J / 2021 / Post-vaccinal minimal change disease / Kidney Int 100(2):459~461 google schola

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