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논문 기본 정보

자료유형
학술저널
저자정보
박상서 (경희대학교) 신말순 (고려대학교) 박혜상 (경희대학교 의과대학 생리학교실) 김태운 (경희대학교의과대학 생리학교실) 김창주 (경희대학교) 임백빈 (동서대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.15 No.3
발행연도
2019.1
수록면
383 - 391 (9page)

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Nicotine withdrawal symptoms comprise insomnia, depression, anxiety, attention disorders, and increased craving. We evaluated the amelio-rating effect of treadmill exercise on nicotine withdrawal symptoms. The rats in the nicotine withdrawal groups received subcutaneous in-jection with 6-mg/kg nicotine hydrogen tartrate salt for 17 days. And then, the injection of nicotine hydrogen tartrate salt was stopped next for 2 weeks. The rats in the exercise groups performed treadmill run-ning once a day, 5 days per week, for 31 days. In the present results, activity was decreased and anxiety-like behavior was observed in the nicotine withdrawal rats. Treadmill running increased activity and ame-liorated anxiety-like behavior in the nicotine-withdrawal rats. Expres-sions of tryptophan hydroxylase (TPH) and 5-hydroxytryptamine (5-HT) in the dorsal raphe were decreased in the nicotine withdrawal rats, in contrast, treadmill running increased TPH and 5-HT expressions. Im-paired short-term memory and deteriorated spatial learning ability were observed in the nicotine withdrawal rats, in contrast, treadmill running ameliorated impairment of short-term memory and spatial learning abil-ity. Expressions of brain-derived neurotrophic factor and tyrosine kinase B (TrkB) were decreased in the nicotine withdrawal rats, in contrast, treadmill running increased brain-derived neurotrophic factor and TrkB expressions. The numbers of the dou¬blecortin (DCX)-positive cells and 5-bromo-2´-deoxyuridine (BrdU)-positive cells in the dentate gyrus were suppressed in the nicotine withdrawal rats, in contrast, treadmill run-ning enhanced the numbers of DCX-positive cells and BrdU-positive cells. The present study demonstrate that treadmill exercise ameliorat-ed nicotine withdrawal-induced anxiety, depression, and memory im-pairment.

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