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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 162 - 168 (7page)
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C-phycocyanin (C-PC), a natural biomaterial, is attracting attention for its unique photodynamic activity, anti- inflammatory and anti-cancer properties. To solve the problem of systemic distribution of photosensitizers, a nano- formulation strategy is essential. The aim of this study is to prepare chitosan-phycocyanin nanoparticles and evaluate their photodynamic therapeutic activity to confirm their potential as a photosensitizer. The average size of chitosan- phycocyanin nanoparticles was measured to be 308.02±3.29 nm and showed a spherical shape. In the DPBF evaluation, ﾠ it was confirmed that the chitosan-phycocyanin nanoparticles generated reactive oxygen species (ROS) under near infrared (NIR) laser irradiation, and the photodynamic activity of phycocyanin was maintained even after particle formation. Although no cytotoxicity was observed with chitosan-phycocyanin nanoparticles, it induced photodynamic therapy- mediated apoptosis in CT26 cells under NIR laser irradiation. All these results indicate that chitosan-phycocyanin nanoparticles could be attractive therapeutics for photodynamic therapy.
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참고문헌 (28)
참고문헌 신청
Li, X. / 2017 / Activatable photosensitizers: agents for selective photodynamic therapy / Adv. Funct. Mater 27:1604053
Lucky, S. S. / 2015 / Nanoparticles in photodynamic therapy / Rev 4:1990~2042
Lee, H. M. / 2014 / Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy / Drug Des. Dev. Ther 8:1451
Wachowska, M. / 2015 / Targeting epigenetic processes in photodynamic therapy-induced anticancer immunity / Front. Oncol 5
Wei, M. F. / 2014 / Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells / Autophagy 10:1179~1192
Lucky, S. S. / 2015 / Nanoparticles in photodynamic therapy / Rev 4:1990~2042
Lee, H. M. / 2014 / Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy / Drug Des. Dev. Ther 8:1451
Wachowska, M. / 2015 / Targeting epigenetic processes in photodynamic therapy-induced anticancer immunity / Front. Oncol 5
Wei, M. F. / 2014 / Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells / Autophagy 10:1179~1192
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