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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
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N-acyl chitosans (N-acyl CSs) with various hydrophobic side chain length were synthesized to improve the resistance in acidic condition. The carrier for gentamicin was developed by N-acyl chitosan nanoparticles (N-acyl CSNPs), which were fabricated through self-aggregation method. N-acyl CSNPs were positive charged from 10.2 to 28.9 mV and the values were decreased from 4.2 to 11.1 mV after gentamicin loading. Particle sizes of N-acyl CSNPs increased from 208 to 480 nm with side chain length. When gentamicin was loaded into N-acyl CSNPs, the particle size decreased by up to 50%. Encapsulation efficiency was around 46-62%. In vitro release profiles of gentamicin in N-acyl CSNPs showed the sustained release properties during one week at pH 1.3 and pH 7.4. Therefore, gentamicin were efficiently loaded into N-acyl CSNPs, these nanoparticles showed a good morphology, nano-size distribution, and controlled release at acidic as well as neutral conditions that permit to propose them as a superior candidate for the delivery of gentamicin.
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참고문헌 (33)
참고문헌 신청
Kissel, T. / 2006 / Microencapsulation: Methods and industrial applications / CRC Press, Taylor & Francis Group :99~121
Kim, B. K. / 2002 / Preparation and characterization of drug-loaded microspheres by an emulsion solvent evaporation method / J. Microencapsulation 19:811~822
Cho, Y. H. / 2003 / Encapsulation of fish oil by an enzymatic gelation process using transglutaminase cross-linked proteins / J. Food Sci 68:2717~2723
Shimoni, E. / 2004 / Stability and shelf life of bioactive compounds during food processing and storage: Soy isolflavones / J. Food Sci. 69:R160~R166
Chen, L. / 2006 / Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds / Biomaterials 27:4646~4654
Kim, B. K. / 2002 / Preparation and characterization of drug-loaded microspheres by an emulsion solvent evaporation method / J. Microencapsulation 19:811~822
Cho, Y. H. / 2003 / Encapsulation of fish oil by an enzymatic gelation process using transglutaminase cross-linked proteins / J. Food Sci 68:2717~2723
Shimoni, E. / 2004 / Stability and shelf life of bioactive compounds during food processing and storage: Soy isolflavones / J. Food Sci. 69:R160~R166
Chen, L. / 2006 / Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds / Biomaterials 27:4646~4654
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