지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 193 - 199 (7page)
이용수
초록· 키워드
오류제보하기
The human FAM190A gene undergoes frequent alteration in human cancer, most commonly involving in-frame deletions in exon 9 or exons 9 & 10. These deletions form novel peptide sequences, serving as presumptive cancer-specific neo antigens. However, it remains elusive whether these in-frame deletions of FAM190A could induce oncogenic properties in vivo. In this study, we aimed to explore the functional significance of in-frame deletions in FAM190A genes. We generated two deletion mutant forms, FAM190AΔexon9 and FAM190AΔexon9& 10, and examined their gain-of-function effects in vitro and in vivo. Global transcript profiling in NIH3T3 cells revealed that the transcripts displaying altered expression following introduction of FAM190AΔexon9 and FAM190AΔexon9& 10 were significantly enriched for genes assigned to cellular movement and cellto- cell signaling, respectively. Furthermore, ectopic expression of FAM190AΔexon9 and FAM190AΔexon9& 10 induced in vivo tumor formation in nu/nu mice. Taken together, our results are the first to demonstrate the in vivo oncogenic properties of in-frame deletions in the FAM190A gene and indicate that these transcript variants might be clinically applicable as therapeutic targets in patients with cancer.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bemmo A / 2010 / Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities / PLoS ONE 5:e11981
Bonomi S / 2013 / Oncogenic alternative splicing switches : role in cancer progression and prospects for therapy / Int J Cell Biol 2013:17
Caceres JF / 2002 / Alternative splicing : multiple control mechanisms and involvement in human disease / Trends Genet 18:186~193
Danckwardt S / 2002 / Abnormally spliced β-globin mRNAs : a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay / Blood 99:1811~1816
Dang L / 2006 / Notch3 signaling initiates choroid plexus tumor formation / Oncogene 25:487~491
Bonomi S / 2013 / Oncogenic alternative splicing switches : role in cancer progression and prospects for therapy / Int J Cell Biol 2013:17
Caceres JF / 2002 / Alternative splicing : multiple control mechanisms and involvement in human disease / Trends Genet 18:186~193
Danckwardt S / 2002 / Abnormally spliced β-globin mRNAs : a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay / Blood 99:1811~1816
Dang L / 2006 / Notch3 signaling initiates choroid plexus tumor formation / Oncogene 25:487~491
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice
Molecules and Cells
2024 .01
-
Mesenchymal-to-epithelial transition of osteoblasts induced by Fam20c knockout
Genes & Genomics
2022 .02
-
Development of Wound Dressing based on Fish Acellular Matrix
한국해양바이오학회지
2024 .12
-
Label/Quencher-Free Detection of Exon Deletion Mutation in Epidermal Growth Factor Receptor Gene Using G-Quadruplex-Inducing DNA Probe
Journal of Microbiology and Biotechnology
2017 .01
-
Fluorometric Detection of Low-Abundance EGFR Exon 19 Deletion Mutation Using Tandem Gene Amplification
Journal of Microbiology and Biotechnology
2020 .01
-
C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1 promotes flowering with TAF15b by repressing the floral repressor gene FLOWERING LOCUS C
Molecules and Cells
2024 .01
-
Association analysis of polymorphism in the NR6A1 gene with the lumbar vertebrae number traits in sheep
Genes & Genomics
2019 .01
-
Mutation Hotspots in the β-catenin Gene : Lessons from Human Cancer Genome Databases
Molecules and Cells
2019 .01
-
On the Convergence of an Optimization Algorithm Based on Nonlinear Operators
East Asian Mathematical Journal
2020 .01
-
TaF: a web platform for taxonomic profile-based fungal gene prediction
Genes & Genomics
2019 .01
-
The SnRK2 family in pepper (Capsicum annuum L.): genome-wide identifcation and expression analyses during fruit development and under abiotic stress
Genes & Genomics
2020 .01
-
Genome-wide identification, characterisation and expression profile analysis of DEAD-box family genes in sweet potato wild ancestor Ipomoea trifida under abiotic stresses
Genes & Genomics
2020 .01
-
Validation of a Fission Yeast Gene Deletion Library by Whole Genome Sequencing
한국미생물학회 학술대회논문집
2022 .10
-
Genetic Change from Colorectal Carcinoma Patients Using Comparative Genomic Hybridization
대한임상검사과학회지
2015 .01
-
Abyssanaerobacter marinus gen. nov., sp. nov., γ-Aminobutyrate-fermenting, Anaerobic Bacterium Isolated from the Onnuri Vent Field of the Indian Ocean and Suggestion of Clostridiales Family XIII Insertae Sedis Emended Mogibacteriaceae fam. nov., Proposal for Phylogenetically Reclassification of Ambiguous This Family’s Genus Member
한국미생물학회 학술대회논문집
2021 .08
-
Deletion diagnostics in fitting a given regression model to a new observation
CSAM(Communications for Statistical Applications and Methods)
2016 .05
-
An Efficient Markerless Deletion System Suitable for the Industrial Strains of Streptomyces
Journal of Microbiology and Biotechnology
2021 .12
-
Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes
Genes & Genomics
2024 .05
-
Construction of Synaptic Neural Network for Genetic Interaction Analysis
Journal of The Korean Data Analysis Society
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0