지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 233 - 240 (8page)
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초록· 키워드
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Background The total length of the cattle genome is approximately ~ 3 billion base pairs. About half of the bovine genome (46.5%) is composed of transposable elements (TEs). The TEs could be a major source of genomic structural variations (SVs) between cattle breeds. These SVs have led to genomic fluidity and rearrangements between interspecies. Objective TE-mediated insertion and deletion events could have a strong influence on the bovine genome. This study aimed to investigate TE-mediated deletion events that are common to 12 Hanwoo genome resequencing data. Results We compared 12 Hanwoo genome resequencing data with the cattle reference genome (Bos taurus_UMD_3.1.1) and six other open source data (2 Jersey, 2 Holstein, 2 Angus). By using BreakDancer program, the common SVs to the 12 Hanwoo genomes were detected. A total of 299 Hanwoo-specific SV candidates were detected. Among them, 56 Hanwoospecific TE-mediated deletion candidate loci were validated by PCR and Sanger sequencing. Finally, we identified one locus, DEL_96, which is an authentic Hanwoo-specific deletion. The DEL_96 event occurred by nonallelic homologous end-joining between LINE (BovB) and unique sequence with 1 bp microhomology. The 370 bp deletion event appeared to be only in the Hanwoo individuals after the divergence of Hanwoo and Holstein lineages. Conclusion Our study showed that one of the SVs, TE-mediated deletion, could be utilized as a molecular maker to distinguish between Hanwoo and Holstein.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Adelson DL / 2009 / Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome / Proc Natl Acad Sci USA 106:12855~12860
Barendse W / 2009 / Genome wide signatures of positive selection : the comparison of independent samples and the identification of regions associated to traits / BMC Genom 10:178
Bentley DR / 2006 / Whole-genome re-sequencing / Curr Opin Genet Dev 16:545~552
Bollongino R / 2012 / Modern taurine cattle descended from small number of near-eastern founders / Mol Biol Evol 29:2101~2104
Bovine HapMap Consortium / 2009 / Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds / Science 324:528~532
Barendse W / 2009 / Genome wide signatures of positive selection : the comparison of independent samples and the identification of regions associated to traits / BMC Genom 10:178
Bentley DR / 2006 / Whole-genome re-sequencing / Curr Opin Genet Dev 16:545~552
Bollongino R / 2012 / Modern taurine cattle descended from small number of near-eastern founders / Mol Biol Evol 29:2101~2104
Bovine HapMap Consortium / 2009 / Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds / Science 324:528~532
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