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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 425 - 439 (15page)
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Background Quantification of mRNAs in gonads and other tissues at the early critical development stage of sex differentiation may help to provide a global view of regulatory mechanisms underlying sex differentiation. We have recently reported the transcriptomic profiling of fugu gonad associated with sex differentiation. Objectives This study attempted to identify the genes in the brain that are involved in gonadal differentiation and development. Methods In this study, a transcriptomic scan of potential candidate genes involved in sex differentiation was conducted in the brains of fugu larvae at 30 and 40 dah (morphological gonadal sex differentiation had not yet occurred). The dimorphic expression patterns of several candidate genes were verified using quantitative PCR. Results A total of 28.24 Gb of clean reads were obtained and 22,337 genes were identified in the brains of fugu larvae. These included 1008 novel genes that provide abundant data for functional analysis of sex differentiation. 229 genes were identified in the 30 dah larvae that were abundant in the XY brain and 21 that were abundant in the XX brain. In the 40 dah larvae, 325 genes were identified abundant in the XY brain and 174 were identified abundant in the XX brain. Conclusion This is the first investigation into the transcriptome of the fugu larvae brain at the early sex differentiation stage. The results obtained here will enhance the understanding of molecular mechanisms that underly fugu sex differentiation.
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참고문헌 (81)
참고문헌 신청
Agate RJ / 2003 / Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch / Proc Natl Acad Sci USA 100:4873~4878
Agate RJ / 2004 / Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches / Mol Biol Evol 21:384~396
Aparicio S / 2002 / Whole genome shotgun assembly and analysis of the genome of Fugu rubripes / Science 297:1301~1310
Arukwe A / 2005 / Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory(StAR)protein and cholesterol side chain cleavage(P450scc)in juvenile Atlantic salmon(Salmo salar)is a novel aspect of nonylphenol toxicity / Environ Sci Technol 39:9791~9798
Arukwe A / 1997 / Xenobiotic and steroid biotransformation enzymes in Atlantic salmon(salmo salar)liver treated with an estrogenic compound, 4-nonylphenol / Environ Toxicol Chem 16:2576~2583
Agate RJ / 2004 / Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches / Mol Biol Evol 21:384~396
Aparicio S / 2002 / Whole genome shotgun assembly and analysis of the genome of Fugu rubripes / Science 297:1301~1310
Arukwe A / 2005 / Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory(StAR)protein and cholesterol side chain cleavage(P450scc)in juvenile Atlantic salmon(Salmo salar)is a novel aspect of nonylphenol toxicity / Environ Sci Technol 39:9791~9798
Arukwe A / 1997 / Xenobiotic and steroid biotransformation enzymes in Atlantic salmon(salmo salar)liver treated with an estrogenic compound, 4-nonylphenol / Environ Toxicol Chem 16:2576~2583
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