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논문 기본 정보

자료유형
학술저널
저자정보
Fangshi Xu (Xi’an Jiaotong University) Yibing Guan (Xi’an Jiaotong University) Peng Zhang (The Second Afliated Hospital of Xi’an Jiaotong University) Li Xue (The Second Afliated Hospital of Xi’an Jiaotong University) Xiaojie Yang (The Second Afliated Hospital of Xi’an Jiaotong University) Ke Gao (Xi’an Jiaotong University) Tie Chong (The Second Afliated Hospital of Xi’an Jiaotong University)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.42 No.9
발행연도
2020.1
수록면
1,055 - 1,066 (12page)

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Background TNFSF14 has been proven to play an important role in various types of tumors. However, its function in renal cell carcinoma (RCC) has not yet been fully elucidated. Objective In order to explore molecular mechanism of RCC, we evaluated the efect of TNFSF14 on RCC progression, prognosis and immune microenvironment. Methods Using TCGA database, the diferential expression of TNFSF14 and its relationships between clinicopathological features and prognosis were determined. Cox univariate and multivariate analyses were successively performed to identify whether TNFSF14 was an independent prognostic factor. The discriminating ability of TNFSF14 in RCC prognosis analysis was validated under the same clinical subgroups. Tumor mutational burden (TMB) of each RCC samples was calculated and the diferential expression of TNFSF14 between high- and low-TMB groups was analyzed. The immune abundances of 22 leukocyte subtypes in each RCC samples were presented through the CIBERSORT algorithm. TIMER database was used to explore the relationships between copy number of TNFSF14 and the infltration levels of 6 immune cells. Results Overexpression of TNFSF14 implied adverse clinicopathological features and poor prognosis. Meanwhile, TNFSF14 was identifed as an independent prognostic factor (HR=1.047, P=0.028) and possessed prevalent applicability in RCC prognostic analysis. TNFSF14 was upregulated in high-TMB group than that in low-TMB group (Log2FC=0.722). Moreover, overexpression of TNFSF14 brought alteration of immune abundance of 8 leukocyte subtypes. Besides, somatic copy number alteration (SCNA) of TNFSF14 was associated with infltration levels of 6 immune cells. Conclusions TNFSF14 has crucial impact on progression, prognosis and immune microenvironment in RCC. Besides, TNFSF14 may be a potential biomarker for predicting the efcacy and response rate of RCC immunotherapy.
#TNFSF14 · Clear cell renal cell carcinoma · TCGA · Immunotherapy · Microenvironment · Tumor mutation burden · TIMER

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참고문헌 (41)

참고문헌 신청
Atkins MB / 2017 / Immune checkpoint inhibitors in advanced renal cell carcinoma : experience to date and future directions / Ann Oncol Off J Eur Soc Med Oncol 28:1484~1494 google schola Brunetti G / 2020 / LIGHT/TNFSF14 promotes osteolytic bone metastases in nonsmall cell lung cancer patients / J Bone Miner Res 35:671~680 google schola Chalmers ZR / 2017 / Analysis of 100, 000 human cancer genomes reveals the landscape of tumor mutational burden / Genome Med 9:34 google schola Chan TA / 2019 / Development of tumor mutation burden as an immunotherapy biomarker : utility for the oncology clinic / Ann Oncol 30:44~56 google schola Chen B / 2018 / Profiling tumor infiltrating immune cells with CIBERSORT / Methods Mol Biol(Clifton, NJ) 1711:243~259 google schola

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