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Comparative genomics of canine Lactobacillus reuteri reveals adaptation to a shared environment with humans
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Comparative genomics of canine Lactobacillus reuteri reveals adaptation to a shared environment with humans

논문 기본 정보

자료유형
학술저널
저자정보
Seungwoo Son (Jeonbuk National University) Jae‑Don Oh (Jeonbuk National University) Sung Ho Lee (Woogene B&G Co. Ltd.) Donghyun Shin (Jeonbuk National University) Yangseon Kim (Center for Industrialization of Agriculture and Livestock Microorganism)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.42 No.9 KCI Accredited Journals
발행연도
2020.1
수록면
1,107 - 1,116 (10page)

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Comparative genomics of canine Lactobacillus reuteri reveals adaptation to a shared environment with humans
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Background Lactobacillus reuteri is a gram-positive, non-motile bacterial species that has been used as a representative microorganism model to describe the ecology and evolution of vertebrate gut symbionts. Objective Because the genetic features and evolutionary strategies of L. reuteri from the gastrointestinal tract of canines remain unknown, we tried to construct draft genome canine L. reuteri and investigate modifed, acquired, or lost genetic features that have facilitated the evolution and adaptation of strains to specifc environmental niches by this study. Methods To examine canine L. reuteri, we sequenced an L. reuteri strain isolated from a dog in Korea. A comparative genomic approach was used to assess genetic diversity and gain insight into the distinguishing features related to diferent hosts based on 27 published genomic sequences. Results The pan-genome of 28 L. reuteri strains contained 7,369 gene families, and the core genome contained 1070 gene families. The ANI tree based on the core genes in the canine L. reuteri strain (C1) was very close to those for three strains (IRT, DSM20016, JCM1112) from humans. Evolutionarily, these four strains formed one clade, which we regarded as C1-clade in this study. We could investigate a total of 32,050 amino acid substitutions among the 28 L. reuteri strain genomes. In this comparison, 283 amino acid substitutions were specifc to strain C1 and four strains in C1-clade shared most of these 283 C1-strain specifc amino acid substitutions, suggesting strongly similar selective pressure. In accessory genes, we could identify 127 C1-clade host-specifc genes and found that several genes were closely related to replication, recombination, and repair. Conclusion This study provides new insights into the adaptation of L. reuteri to the canine intestinal habitat, and suggests that the genome of L. reuteri from canines is closely associated with their living and shared environment with humans.
#Lactobacillus reuteri · Comparative genomics · Pan-genome analysis · Host adaptation · Dog

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참고문헌 (27)

참고문헌 신청
Denamur E / 2006 / Evolution of mutation rates in bacteria / Mol Microbiol 60:820~827 google schola Duar RM / 2017 / Experimental evaluation of host adaptation of lactobacillus reuteri to different vertebrate species / Appl Environ Microbiol 83:e00132~e01117 google schola Francis F / 2013 / Comparative genomic analysis of two Burkholderia glumae strains from different geographic origins reveals a high degree of plasticity in genome structure associated with genomic islands / Mol Genet Genom 288:195~203 google schola Frese SA / 2011 / The evolution of host specialization in the vertebrate gut symbiont lactobacillus reuteri / PLoS Genet 7:e1001314 google schola Frost LS / 2005 / Mobile genetic elements : the agents of open source evolution / Nat Rev Microbiol 3:722 google schola

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