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논문 기본 정보

자료유형
학술저널
저자정보
김미화 (University of Ulsan College of Medicine) 김은숙 (울산대학교) 김보현 (부산대학교) 김희경 (전남대학교) 이현승 (충남대학교병원) 전민지 (울산대학교) 김태용 (울산대학교) 강호철 (전남대학교) 김원배 (울산대학교) 송영기 (울산대학교) 김미진 (부산대학교병원) 김원구 (울산대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.3
발행연도
2020.1
수록면
618 - 627 (10page)

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Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification(WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods: This multicenter retrospective cohort study included 318 patients with FTC from five tertiary centers who underwent thyroid surgery between 1996 and 2009. We evaluated the prognosis of patients with minimally invasive (MI), encapsulated angioinvasive (EA), and widely invasive (WI) FTC according to WHO-2017. Further, we evaluated the proportion of variation explained(PVE) and Harrell’s C-index to compare the predictability of disease-free survival (DFS) and disease-specific survival (DSS). Results: In total, 227, 58, and 33 patients had MI-, EA-, and WI-FTC, respectively. During a median follow-up of 10.6 years, 46(14.5%) patients had disease recurrence and 20 (6.3%) patients died from FTC. The 10-year DFS rates of patients with MI-, EA-,and WI-FTC were 91.1%, 78.2%, and 54.9%, respectively (P<0.001, PVE=7.1%, C-index=0.649). The corresponding 10-yearDSS rates were 95.9%, 93.5%, and 73.5%, respectively (P<0.001, PVE=2.6%, C-index=0.624). The PVE and C-index values werehigher using WHO-2017 than using WHO-2004 for the prediction of DFS, but not for DSS. In multivariate analysis, older age(P=0.02), gross extrathyroidal extension (ETE) (P=0.003), and distant metastasis (P<0.001) were independent risk factors for DSS. Conclusion: WHO-2017 improves the predictability of DFS, but not DSS, in patients with FTC. Distant metastasis, gross ETE andolder age (≥55 years) were independent risk factors for DSS.

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