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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 756 - 764 (9page)
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초록· 키워드
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The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newlyestablished technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.
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등록된 정보가 없습니다.
참고문헌 (62)
참고문헌 신청
Lala DS / 1992 / Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I / Mol Endocrinol 6:1249~1258
Morohashi K / 1992 / A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s / J Biol Chem 267:17913~17919
Honda S / 1993 / Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily / J Biol Chem 268:7494~7502
Morohashi Ki / 1999 / Gonadal and extragonadal functions of Ad4BP/SF-1 : developmental aspects / Trends Endocrinol Metab 10:169~173
Parker KL / 1997 / Steroidogenic factor 1 : a key determinant of endocrine development and function / Endocr Rev 18:361~377
Morohashi K / 1992 / A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s / J Biol Chem 267:17913~17919
Honda S / 1993 / Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily / J Biol Chem 268:7494~7502
Morohashi Ki / 1999 / Gonadal and extragonadal functions of Ad4BP/SF-1 : developmental aspects / Trends Endocrinol Metab 10:169~173
Parker KL / 1997 / Steroidogenic factor 1 : a key determinant of endocrine development and function / Endocr Rev 18:361~377
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