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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 954 - 959 (6page)
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초록· 키워드
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Insulin-like growth factor-I (IGF-I) plays a pivotal role in the diagnosis and treatment of growth hormone (GH) excess or deficiency. The GH study group of the Korean Endocrine Society aims to establish the Korean reference ranges of serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) and assess the relationship between IGF-I and IGFBP-3 and clinical parameters. Fasting serum was collected from healthy Korean adults at health promotion centers of five hospitals nationwide. Serum IGF-I and IGFBP-3 were measured via an immunoradiometric assay using a DSL kit (Diagnostic Systems Laboratories). Serum samples from 354 subjects (180 male, 174 female) were analyzed based on sex at 10-year intervals from 21 to 70 years. IGF-I levels were inversely correlated with age. After adjustment of age, the IGF-I/IGFBP-3 ratio was significantly negatively associated with blood pressure and free thyroxine and positively associated with weight, hemoglobin, creatinine, alanine transferase, fasting glucose, and thyroid stimulating hormone. Therefore, age- and sex-specific reference ranges of serum IGF-I and IGFBP-3 can be efficient in evaluating GH excess or deficiency in Korean population.
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참고문헌 (17)
참고문헌 신청
Hyun SE / 2012 / Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents / Clin Biochem 45:16~21
Baxter RC / 1998 / Recommendations for nomenclature of the insulin-like growth factor binding protein superfamily / Endocrinology 139:4036
Juul A / 1994 / Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults : relation to age, sex, stage of puberty, testicular size, and body mass index / J Clin Endocrinol Metab 78:744~752
Bidlingmaier M / 2014 / Reference intervals for insulinlike growth factor-1(igf-i)from birth to senescence : results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations / J Clin Endocrinol Metab 99:1712~1721
Zhu H / 2017 / Reference ranges for serum insulin-like growth factor I(IGF-I)in healthy Chinese adults / PLoS One 12:e0185561
Baxter RC / 1998 / Recommendations for nomenclature of the insulin-like growth factor binding protein superfamily / Endocrinology 139:4036
Juul A / 1994 / Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults : relation to age, sex, stage of puberty, testicular size, and body mass index / J Clin Endocrinol Metab 78:744~752
Bidlingmaier M / 2014 / Reference intervals for insulinlike growth factor-1(igf-i)from birth to senescence : results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations / J Clin Endocrinol Metab 99:1712~1721
Zhu H / 2017 / Reference ranges for serum insulin-like growth factor I(IGF-I)in healthy Chinese adults / PLoS One 12:e0185561
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