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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 81 - 95 (15page)
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초록· 키워드
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Background: Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules. Methods: We conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome. Results: The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia. Conclusion: The role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.
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참고문헌 (62)
참고문헌 신청
Russ G / 2014 / Thyroid incidentalomas : epidemiology, risk stratification with ultrasound and workup / Eur Thyroid J 3:154~163
Rojeski MT / 1985 / Nodular thyroid disease. Evaluation and management / N Engl J Med 313:428~436
Durante C / 2018 / The diagnosis and management of thyroid nodules : a review / JAMA 319:914~924
Smith MD / 2003 / Fine needle aspiration in the management of benign thyroid cysts / ANZ J Surg 73:477~479
Choi WJ / 2015 / Management of cystic or predominantly cystic thyroid nodules : role of simple aspiration of internal fluid / Endocr Res 40:215~219
Rojeski MT / 1985 / Nodular thyroid disease. Evaluation and management / N Engl J Med 313:428~436
Durante C / 2018 / The diagnosis and management of thyroid nodules : a review / JAMA 319:914~924
Smith MD / 2003 / Fine needle aspiration in the management of benign thyroid cysts / ANZ J Surg 73:477~479
Choi WJ / 2015 / Management of cystic or predominantly cystic thyroid nodules : role of simple aspiration of internal fluid / Endocr Res 40:215~219
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