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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 312 - 321 (10page)
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초록· 키워드
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Immune-related adverse events (irAEs) affecting the endocrine glands are among the most frequent irAEs induced by immunecheckpoint inhibitors (ICIs) and include hypopituitarism, primary adrenal insufficiency, thyrotoxicosis, hypothyroidism, hypoparathyroidism, and type 1 diabetes mellitus. Since the incidence and clinical features of endocrine irAEs vary according to the ICI used,it is important to understand the characteristics of these irAEs and to manage each one appropriately. Since some endocrine irAEs,including adrenal crisis and diabetic ketoacidosis, are potentially life-threatening, predicting the risk of endocrine irAEs before theironset is critical. Several autoantibodies have been detected in patients who develop endocrine irAEs, among which anti-thyroid antibodies may be predictive biomarkers of thyroid dysfunction. In this review, we describe the clinical features of each endocrine irAEinduced by ICIs and discuss their potential biomarkers, including autoantibodies.
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참고문헌 (55)
참고문헌 신청
Brahmer JR / 2018 / Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy : American Society of Clinical Oncology clinical practice guideline / J Clin Oncol 36:1714~1768
Puzanov I / 2017 / Managing toxicities associated with immune checkpoint inhibitors : consensus recommendations from the Society for Immunotherapy of Cancer(SITC)Toxicity Management Working Group / J Immunother Cancer 5:95
Arima H / 2019 / Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors : clinical guidelines of the Japan Endocrine Society / Endocr J 66:581~586
Zhai Y / 2019 / Endocrine toxicity of immune checkpoint inhibitors : a real-world study leveraging US Food and Drug Administration adverse events reporting system / J Immunother Cancer 7:286
Byun DJ / 2017 / Cancer immunotherapy : immune checkpoint blockade and associated endocrinopathies / Nat Rev Endocrinol 13:195~207
Puzanov I / 2017 / Managing toxicities associated with immune checkpoint inhibitors : consensus recommendations from the Society for Immunotherapy of Cancer(SITC)Toxicity Management Working Group / J Immunother Cancer 5:95
Arima H / 2019 / Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors : clinical guidelines of the Japan Endocrine Society / Endocr J 66:581~586
Zhai Y / 2019 / Endocrine toxicity of immune checkpoint inhibitors : a real-world study leveraging US Food and Drug Administration adverse events reporting system / J Immunother Cancer 7:286
Byun DJ / 2017 / Cancer immunotherapy : immune checkpoint blockade and associated endocrinopathies / Nat Rev Endocrinol 13:195~207
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