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자료유형
학술저널
저자정보
조윤정 (가톨릭대학교) 한경도 (숭실대학교) 김다혜 (Department of Biostatistics College of Medicine The Catholic University of Korea) 박용문 (University of Arkansas for Medical Sciences USA) 윤건호 (가톨릭대학교) 김미경 (가톨릭대학교) 이승환 (가톨릭대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.2
발행연도
2021.1
수록면
424 - 435 (12page)

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Background: Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS)and its components changes over time, we aimed to investigate the association of the cumulative exposure to MetS and its components with the risk of dementia. Methods: Adults (n=1,492,776; ≥45-years-old) who received health examinations for 4 consecutive years were identified from anationwide population-based cohort in Korea. Two exposure-weighted scores were calculated: cumulative number of MetS diagnoses (MetS exposure score, range of 0 to 4) and the composite of its five components (MetS component exposure score, range of 0 to20). Hazard ratio (HR) and 95% confidence interval (CI) values for dementia were analyzed using the multivariable Cox proportional-hazards model. Results: Overall, 47.1% of subjects were diagnosed with MetS at least once, and 11.5% had persistent MetS. During the mean 5.2years of follow-up, there were 7,341 cases (0.5%) of incident dementia. There was a stepwise increase in the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia with increasing MetS exposure score and MetS component exposure score (each P fortrend <0.0001). The HR of all-cause dementia was 2.62 (95% CI, 1.87 to 3.68) in subjects with a MetS component exposure score of20 compared with those with a score of 0. People fulfilling only one MetS component out of 20 already had an approximately 40%increased risk of all-cause dementia and Alzheimer’s disease. Conclusion: More cumulative exposure to metabolic disturbances was associated with a higher risk of dementia. Of note, even minimal exposure to MetS components had a significant effect on the risk of dementia.

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