Relationships between Islet-Specific Autoantibody Titers and the Clinical Characteristics of Patients with Diabetes Mellitus

Yiqian Zhang; Tong Yin; Xinlei Wang; Rongping Zhang; Jie Yuan; Yi Sun; Jing Zong; Shiwei Cui; Yunjuan Gu

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저자정보: Yiqian Zhang (Affiliated Hospital of Nantong University) Tong Yin (Affiliated Hospital of Nantong University) Xinlei Wang (Affiliated Hospital of Nantong University) Rongping Zhang (Affiliated Hospital of Nantong University) Jie Yuan (Affiliated Hospital of Nantong University) Yi Sun (Affiliated Hospital of Nantong University) Jing Zong (Affiliated Hospital of Nantong University) Shiwei Cui (Affiliated Hospital of Nantong University) Yunjuan Gu (Affiliated Hospital of Nantong University)

저널정보: 대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.45 No.3

발행연도: 2021.1

수록면: 404 - 416 (13page)

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Background: Dysimmunity plays a key role in diabetes, especially type 1 diabetes mellitus. Islet-specific autoantibodies (ISAs) have been used as diagnostic markers for different phenotypic classifications of diabetes. This study was aimed to explore the relationships between ISA titers and the clinical characteristics of diabetic patients. Methods: A total of 509 diabetic patients admitted to Department of Endocrinology and Metabolism at the Affiliated Hospital of Nantong University were recruited. Anthropometric parameters, serum biochemical index, glycosylated hemoglobin, urinary microalbumin/creatinine ratio, ISAs, fat mass, and islet β-cell function were measured. Multiple linear regression analysis was performed to identify relationships between ISA titers and clinical characteristics. Results: Compared with autoantibody negative group, blood pressure, weight, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), visceral fat mass, fasting C-peptide (FCP), 120 minutes C-peptide (120minCP) and area under C-peptide curve (AUCCP) of patients in either autoantibody positive or glutamate decarboxylase antibody (GADA) positive group were lower. Body mass index (BMI), waist circumference, triglycerides (TGs), body fat mass of patients in either autoantibody positive group were lower than autoantibody negative group. GADA titer negatively correlated with TC, LDL-C, FCP, 120minCP, and AUCCP. The islet cell antibody and insulin autoantibody titers both negatively correlated with body weight, BMI, TC, TG, and LDL-C. After adjusting confounders, multiple linear regression analysis showed that LDL-C and FCP negatively correlated with GADA titer. Conclusion: Diabetic patients with a high ISA titer, especially GADA titer, have worse islet β-cell function, but less abdominal obesity and fewer features of the metabolic syndrome.

#Diabetes mellitus #Diabetic angiopathies #Glutamate decarboxylase #Insulin-secreting cells #Islet cell antibody #Metabolic syndrome

참고문헌 (38)

참고문헌 신청

Winter WE / 2013 / The clinical application of islet autoantibody testing for the diagnosis of autoimmune diabetes / MLO Med Lab Obs 45:16

Palmer JP / 1983 / Insulin antibodies in insulin-dependent diabetics before insulin treatment / Science 222:1337~1339

Baekkeskov S / 1990 / Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase / Nature 347:151~156

Rabin DU / 1992 / Cloning and expression of IDDM-specific human autoantigens / Diabetes 41:183~186

Wenzlau JM / 2007 / The cation efflux transporter ZnT8(Slc30A8)is a major autoantigen in human type 1 diabetes / Proc Natl Acad Sci U S A 104:17040~17045

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