지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 217 - 224 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The purpose of this study was to investigate the effects of kartogenin (KGN) on the tendon-bone interface in a rat rotator cuff tear model. Methods: Twenty male rats were divided into two equal groups; group 1 (repair only) and group 2 (KGN single injection). A rat rotator cuff rupture model was prepared, and KGN (500 μM) was injected into the repair site. The specimens were collected after 8 weeks, and biomechanical and histological analyses were performed. We assessed the healing quality of the tendon-to-bone repair site using six aspects of tendon tissue. The histological findings were classified semiquantitatively into four grades (grade 0, the poorest appearance; grade 1, poorer; grade 2, better; and grade 3, marked regeneration). Results: Group 2 showed a higher mean ultimate load to failure than the control group (group 1: 25.78±31.38 N, group 2: 55.64±36.02 N; p=0.011). On histological analysis, group 2 exhibited a significantly greater total score (group 1: 7.20±2.14, group 2: 9.50±1.84; p=0.019), collagen fiber continuity (group 1: 1.20±0.42, group 2: 1.70±0.48; p=0.024), and collagen fiber density (group 1: 1.50±0.52, group 2: 2.20±0.63; p=0.080). Metachromasia were more intense in group 2 than in the control group. Conclusion: A single injection of KGN reinforces biomechanical strength and the formation of collagen and fibrocartilage at the tendon-to-bone interface in a rat rotator cuff tear model.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Yamaguchi K / 2006 / The demographic and morphological features of rotator cuff disease : a comparison of asymptomatic and symptomatic shoulders / J Bone Joint Surg Am 88:1699~1704
Wang VM / 2010 / Medial versus lateral supraspinatus tendon properties : implications for doublerow rotator cuff repair / Am J Sports Med 38:2456~2463
Le BT / 2014 / Factors predicting rotator cuff retears : an analysis of 1000 consecutive rotator cuff repairs / Am J Sports Med 42:1134~1142
Castricini R / 2011 / Platelet-rich plasma augmentation for arthroscopic rotator cuff repair : a randomized controlled trial / Am J Sports Med 39:258~265
Wang LL / 2018 / Platelet-derived growth factor subunit B is required for tendon-bone healing using bone marrow-derived mesenchymal stem cells after rotator cuff repair in rats / J Cell Biochem 119:8897~8908
Wang VM / 2010 / Medial versus lateral supraspinatus tendon properties : implications for doublerow rotator cuff repair / Am J Sports Med 38:2456~2463
Le BT / 2014 / Factors predicting rotator cuff retears : an analysis of 1000 consecutive rotator cuff repairs / Am J Sports Med 42:1134~1142
Castricini R / 2011 / Platelet-rich plasma augmentation for arthroscopic rotator cuff repair : a randomized controlled trial / Am J Sports Med 39:258~265
Wang LL / 2018 / Platelet-derived growth factor subunit B is required for tendon-bone healing using bone marrow-derived mesenchymal stem cells after rotator cuff repair in rats / J Cell Biochem 119:8897~8908
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