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논문 기본 정보

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학술저널
저자정보
Sandra Villanueva (Universidad de Los Andes Santiago Chile) Fernando González (Department of Nephrology Hospital Salvador Santiago Chile) Eduardo Lorca (Department of Nephrology Hospital Salvador Santiago Chile) Andrés Tapia (Universidad de Los Andes Santiago Chile) Valentina López G (Universidad de Los Andes Santiago Chile) Rocío Strodthoff (Faculty of Medicine Universidad de Los Andes Santiago Chile) Francisca Fajre (Faculty of Medicine Universidad de Los Andes Santiago Chile) Juan E. Carreño (Faculty of Medicine Universidad de Los Andes Santiago Chile) Ricardo Valjalo (Department of Nephrology Hospital Salvador Santiago Chile) César Vergara (Faculty of Medicine Universidad de Los Andes Santiago Chile) Manuel Lecanda (aculty of Medicine Universidad de Los Andes Santiago Chile) Jorge Bartolucci (Universidad de Los Andes Santiago Chile) Fernando E. Figueroa (Faculty of Medicine Universidad de Los Andes Santiago Chile) Maroun Khoury (Faculty of Medicine Universidad de Los Andes Santiago Chile)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.38 No.2
발행연도
2019.1
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176 - 185 (10page)

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Background: Chronic kidney disease (CKD) is a growing public health concern, and available treatments are insufficient in limiting disease progression. New strategies, including regenerative cell-based therapies, have emerged as therapeutic alternatives. Results from several groups, including our own, have reported evidence of a supportive role for mesenchymal stromal cells (MSCs) in functional recovery and prevention of tissue damage in murine models of CKD. Prompted by these data, an open pilot study was conducted to assess the safety and efficacy of a single injection of autologous adipose tissue-derived MSCs (AT-MSCs) for treatment of CKD. Methods: AT-MSCs were infused intravenously into six CKD patients at a dose of 1 million cells/kg. Patients were stabilized and followed for one year prior to MSC infusion and one year following infusion. Results: No patients presented with adverse effects. Statistically significant improvement in urinary protein excretion was observed in AT-MSCs transplanted patients, from a median of 0.75 g/day (range, 0.15-9.57) at baseline to 0.54 g/day (range, 0.01-2.66) at month 12 (P = 0.046). The glomerular filtration rate was not significantly decreased post-infusion of AT-MSCs. Conclusion: Findings from this pilot study demonstrate that intravenous infusion of autologous expanded AT-MSCs into CKD patients was not associated with adverse effects and could benefit patients already undergoing standard medical treatment.
#Adipose tissue-derived mesenchymal stromal cells #Chronic kidney disease #Mesenchymal stromal cell transplantation #Proteinuria #Stem cells

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참고문헌 (39)

참고문헌 신청
Coresh J / 2005 / Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000 / J Am Soc Nephrol 16:180~188 google schola Shishehbor MH / 2008 / Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease / Am J Cardiol 101:1741~1746 google schola Navaneethan SD / 2009 / Aldosterone antagonists for preventing the progression of chronic kidney disease / Cochrane Database Syst Rev (3):CD007004 google schola Alexandre CS / 2009 / Lineagenegative bone marrow cells protect against chronic renal failure / Stem Cells 27:682~692 google schola Traktuev DO / 2008 / A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks / Circ Res 102:77~85 google schola

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