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논문 기본 정보

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학술저널
저자정보
Khalil Rania (Biochemistry Department Faculty of Pharmacy Delta University for Science and Technology Gamasa Egyp) Elghadban Hosam (General Surgery Department Faculty of Medicine Mansoura University Mansoura Egypt) Abdelsalam Moustafa (Internal Medicine Department Mansoura Nephrology and Dialysis Unit Faculty of Medicine Mansoura Uni) Tawfik Mona (Internal Medicine Department Mansoura Nephrology and Dialysis Unit Faculty of Medicine Mansoura Uni)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.39 No.2
발행연도
2020.1
수록면
162 - 171 (10page)

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Background: Bariatric surgeries were reported to improve diabetes and hypertension; however, the effect on renal recovery has not been fully explored. The aim of this study was to evaluate the effect of laparoscopic sleeve gastrectomy (LSG) in morbidly obese patients on renal function, degree of albuminuria, and kidney injury molecule-1 (KIM-1) level. Methods: This was a prospective observational study conducted at Mansoura University Hospitals from January to June 2017. Forty-four morbidly obese patients (29 females and 15 males) who met the 1991 WHO criteria for obesity surgery were included. Patients underwent surgical LSG for treatment of morbid obesity, and all were followed for 6 months after surgery. Demographic, clinical, and laboratory data were collected and compared before and after surgery. Primary endpoints were the differences of albuminuria, estimated glomerular filtration rate (eGFR) and serum KIM-1 between baseline (pre-surgery) and 6-month post-surgery values. Results: Six-month post-surgery data showed significant reduction of body mass index, HbA1c, microalbuminuria, and serum KIM-1, and a significant increase in eGFR (all, P < 0.001). The serum KIM-1 level positively correlated with microalbuminuria and serum creatinine (r = 0.596, P = 0.001 and r = 0.402, P = 0.034, respectively). Postoperative data showed that patients with microalbuminuria had significantly lower eGFR and higher KIM-1 values than those without microalbuminuria (P = 0.003 and 0.049, respectively). Conclusion: We showed potential benefits of LSG against obesity-associated kidney damage. This is evidenced by improving eGFR and reducing levels of both KIM-1 and microalbuminuria. The serum level of KIM-1 may be a potential marker for renal recovery after LSG.
#Albuminuria #Kidney injury molecule-1 #Laparoscopic sleeve gastrectomy #Obesity

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참고문헌 (40)

참고문헌 신청
Hutter MM / 2011 / First report from the American College of Surgeons Bariatric Surgery Center Network : laparoscopic sleeve gastrectomy has morbidity and effectiveness positioned between the band and the bypass / Ann Surg 254:410~420 google schola Lee SY / 2011 / Laparoscopic sleeve gastrectomy : a novel procedure for weight loss / Singapore Med J 52:794~800 google schola Yousseif A / 2014 / Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans / Obes Surg 24:241~252 google schola Aggarwal S / 2007 / Laparoscopic sleeve gastrectomy for morbid obesity : a review / Surg Obes Relat Dis 3:189~194 google schola Bohdjalian A / 2010 / Sleeve gastrectomy as sole and definitive bariatric procedure : 5-year results for weight loss and ghrelin / Obes Surg 20:535~540 google schola

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