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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 118 - 127 (10page)
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초록· 키워드
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Background: Graft survival rate of kidney transplantation recipients improves after induction therapy. However, there is no conclusive evidence on which regimen is superior for deceased donor kidney transplantation (DDKT). This study aims at discussing effective induction therapy in DDKT. Methods: Between 2003 and 2016, 395 DDKT recipients were divided into three groups following induction therapy. Recipients of the basiliximab group (n=184) received basiliximab (20 mg/kg) on days 0 and 4. Recipients of the low-dose rabbit anti-thymocyte globulin (rATG) group (n=113) received rATG (1.5 mg/kg) on days 0, 1, and 2, while those of the high-dose rATG group (n=98) received it for more than 4 days. We retrospectively reviewed and analyzed the clinical outcomes and adverse effects of induction therapy. Results: Compared to other groups, the low-dose rATG group donors were older (P＜0.001); rATG group donors had higher serum creatinine levels (P＜0.001), and the basiliximab group showed a lower delayed graft function rate (P=0.004). In graft failure, the low-dose rATG group did not differ significantly from the basiliximab group (P=0.080), but was significantly different from the high-dose rATG group (P=0.004). Conclusions: The low-dose rATG group had the best graft survival rate, although it had older donors and higher serum creatinine levels. Therefore, low-dose rATG may be considered an effective induction therapy in DDKT.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Hariharan S / 2000 / Improved graft survival after renal transplantation in the United States, 1988 to 1996 / N Engl J Med 342:605~612
Hariharan S. / 2001 / Long-term kidney transplant survival / Am J Kidney Dis 38(6 Suppl 6):S44~S50
Bourdage JS / 1995 / Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry / Transplantation 59:1194~1200
Zand MS / 2005 / Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways / Transplantation 79:1507~1515
Amlot PL / 1995 / Prolonged action of a chimeric interleukin-2 receptor (CD25) monoclonal antibody used in cadaveric renal transplantation / Transplantation 60:748~756
Hariharan S. / 2001 / Long-term kidney transplant survival / Am J Kidney Dis 38(6 Suppl 6):S44~S50
Bourdage JS / 1995 / Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry / Transplantation 59:1194~1200
Zand MS / 2005 / Polyclonal rabbit antithymocyte globulin triggers B-cell and plasma cell apoptosis by multiple pathways / Transplantation 79:1507~1515
Amlot PL / 1995 / Prolonged action of a chimeric interleukin-2 receptor (CD25) monoclonal antibody used in cadaveric renal transplantation / Transplantation 60:748~756
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