지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 1 - 7 (7page)
이용수
초록· 키워드
오류제보하기
Background: To analyze transplant rejection and to distinguish between donor and recipient, it is necessary to select a marker from single nucleotide polymorphism (SNP), short tandem repeat (STR), and human leukocyte antigen (HLA) testing. SNPs are bi-allelic and the polymerase chain reaction method used for SNP testing has the advantage of lower cost than sequencing methods. In this study, we aimed to distinguish donors from recipients using a combination of existing commercialized STRs and the SNPs identified. Methods: All selected SNPs complied with the following criterion: known and validated minor allele frequency (MAF) ≥43% in Korean and reported ethnicities from global populations (HapMap, 1000 Genomes, and the Korean Reference Genome project). The STR assays were performed for 16 tetranucleotide repeat loci. Results: DNA from the 52 donor/recipient pairs were tested for informative markers. The median age of the recipients was 47 years. MAF in the 52 pairs was 1.0%–76.0%. The probability of informative genotypes (I) was 0.001–0.124. The summation of I was 0.680. In the 52 donor recipient pairs, the selected SNPs showed a 0.031 average probability of being informative. The probability of identity in our study was 0.122–0.348. SNP panel configuration distinguished 100% of 52 donors/recipient pairs. Conclusions: Donors and recipients were distinguished by STR and 22 SNPs with MAF identified from SNP databases. Seventeen SNPs were able to distinguish between donors and recipients (I value=0.039).
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Snyder TM / 2011 / Universal noninvasive detection of solid organ transplant rejection / Proc Natl Acad Sci U S A 108:6229~6234
Gielis EM / 2015 / Cell-free DNA : an upcoming biomarker in transplantation / Am J Transplant 15:2541~2551
Pontes ML / 2015 / SNP markers as additional information to resolve complex kinship cases / Transfus Med Hemother 42:385~388
Beck J / 2013 / Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury / Clin Chem 59:1732~1741
Thongprayoon C / 2020 / The use of donor-derived cellfree DNA for assessment of allograft rejection and injury status / J Clin Med 9:1480
Gielis EM / 2015 / Cell-free DNA : an upcoming biomarker in transplantation / Am J Transplant 15:2541~2551
Pontes ML / 2015 / SNP markers as additional information to resolve complex kinship cases / Transfus Med Hemother 42:385~388
Beck J / 2013 / Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury / Clin Chem 59:1732~1741
Thongprayoon C / 2020 / The use of donor-derived cellfree DNA for assessment of allograft rejection and injury status / J Clin Med 9:1480
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Living donor liver transplantation using donors older than 50 years of age: Recipient criteria and donor risk
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
The outcomes of marginal donor hearts compared with ideal donors: a single-center experience in Iran
Clinical Transplantation and Research
2022 .06
-
Donor sex and donor-recipient sex disparity do not affect hepatocellular carcinoma recurrence after living donor liver transplantation
Annals of Surgical Treatment and Research
2023 .09
-
Recipient efficacy and safety of kidney transplantation from older living donor: consideration for using older kidney as a solution to the shortage of organs
Clinical Transplantation and Research
2021 .12
-
Impact of extended living donor criteria focusing on donor safety in living donor liver transplantation
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Survival Outcome of Split Liver Transplantation Compared to That of Whole Liver Transplantation : Concern of Donor Weight to Recipient Weigh Ratio in Adult Recipients
대한외과학회 학술대회 초록집
2017 .11
-
Establishment of a Tm-shift Method for Detection of Cat-Derived Hookworms
Parasites, Hosts and Diseases
2019 .02
-
Genetic predisposition of donors affects the allograft outcome in kidney transplantation: Single-nucleotide polymorphism of aquaporin-11
Kidney Research and Clinical Practice
2015 .01
-
Can the bone marrow harvest volume be reduced safely in hematopoietic stem cell transplantation with pediatric sibling donors?
Blood Research
2023 .03
-
Cancer Risk Score Prediction Based on a Single-Nucleotide Polymorphism Network
Healthcare Informatics Research
2022 .07
-
[Vascular Surgery/ Transplantation] Cysteine as a Potential Donor Urinary Biomarker for Donor Acute Kidney Injury and Recipient Early Graft Function
대한외과학회 학술대회 초록집
2022 .05
-
Outcomes of deceased donor liver transplantation from elderly donors
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Effect of donor against recipient one-way mismatch on graft-versus-host-disease after liver transplantation
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Weight reduction of the donor in hepatic steatosis for living donor liver transplantation as a tool in expanding the donor pool
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Donor wound satisfaction after living donor liver transplantation in the Era of pure laparoscopic donor hepatectomy
대한외과학회 학술대회 초록집
2017 .11
-
Outcomes of deceased donor liver transplantation from elderly donors
Clinical Transplantation and Research
2021 .01
-
MMPI-2를 이용한 생체 간 공여자들의 심리적 특성에 대한 연구
정신신체의학
2019 .01
-
Management of potential cardiac donors
Clinical Transplantation and Research
2024 .03
-
Barriers to the identification of possible organ donors among brain-injured patients admitted to intensive care units
Clinical Transplantation and Research
2023 .06
-
A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation
Kidney Research and Clinical Practice
2023 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0