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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 150 - 163 (14page)
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Ependymal stem cells (EpSCs) are dormant stem cells in the adult spinal cord that proliferate rapidly and migrate to the site of injury after spinal cord injury (SCI). Although they can differentiate into neurons under appropriate conditions in vitro, EpSCs mainly differentiate into astrocytes in vivo. Our previous study confirmed that alternatively polarized macrophages (M2) facilitate the differentiation of EpSCs towards neurons, but the detailed mechanism remains elusive. In the present study, we found that M2 conditioned medium could upregulate the expression of Sirtuin 2 (SIRT2) in EpSCs in vitro through the BDNF/TrkB-MEK/ERK signaling pathway. As an important deacetylase, SIRT2 deacetylated stable Ac-α- tubulin (Acetyl alpha Tubulin) in microtubules and thus promoted EpSC differentiation into neurons. The present study provides a theoretical basis and a new way to improve neural recovery, such as regulating the growth and differentiation of EpSCs by increasing the proportion of M2 cells in the local microenvironment or upregulating the expression of SIRT2 in EpSCs.
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참고문헌 (36)
참고문헌 신청
Park HW / 2018 / Olig2-expressing mesenchymal stem cells enhance functional recovery after contusive spinal cord injury / Int J Stem Cells 11:177~186
Piltti KM / 2017 / Increasing human neural stem cell transplantation dose alters oligodendroglial and neuronal differentiation after spinal cord injury / Stem Cell Reports 8:1534~1548
Sankavaram SR / 2019 / Adult neural progenitor cells transplanted into spinal cord injury differentiate into oligodendrocytes, enhance myelination, and contribute to recovery / Stem Cell Reports 12:950~966
Cawsey T / 2015 / Nestinpositive ependymal cells are increased in the human spinal cord after traumatic central nervous system injury / J Neurotrauma 32:1393~1402
Lacroix S / 2014 / Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions / PLoS One 9:e85916
Piltti KM / 2017 / Increasing human neural stem cell transplantation dose alters oligodendroglial and neuronal differentiation after spinal cord injury / Stem Cell Reports 8:1534~1548
Sankavaram SR / 2019 / Adult neural progenitor cells transplanted into spinal cord injury differentiate into oligodendrocytes, enhance myelination, and contribute to recovery / Stem Cell Reports 12:950~966
Cawsey T / 2015 / Nestinpositive ependymal cells are increased in the human spinal cord after traumatic central nervous system injury / J Neurotrauma 32:1393~1402
Lacroix S / 2014 / Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions / PLoS One 9:e85916
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