메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Da Hyun Jung (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea) Cheal Wung Huh (Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine) Sang Kil Lee (Division of Gastroenterology Department of Internal Medicine Severance Hospital Yonsei University C) Jun Chul Park (Department of Gastroenterology Yonsei University Severance Hospital Seoul Korea) Sung Kwan Shin (Department of Internal Medicine Severance Hospital Yonsei University College of Medicine Korea) Yong Chan Lee (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.2
발행연도
2021.1
수록면
165 - 175 (11page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/AimsProkinetics can be used for treating patients with gastroesophageal reflux disease (GERD), who exhibit suboptimal response to proton pump inhibitor (PPI) treatment. We conducted a systematic review to assess the potential benefits of combination treatment with PPI plus prokinetics in GERD. MethodsWe searched PubMed, the Cochrane Library, and EMBASE for publications regarding randomized controlled trials comparing combination treatment of PPI plus prokinetics to PPI monotherapy with respect to global symptom improvement in GERD (until February 2020). The primary outcome was an absence or global symptom improvement in GERD. Adverse events and quality of life (QoL) scores were evaluated as secondary outcomes using a random effects model. Quality of evidence was rated using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). ResultsThis meta-analysis included 16 studies involving 1446 participants (719 in the PPI plus prokinetics group and 727 in the PPI monotherapy group). The PPI plus prokinetics treatment resulted in a significant reduction in global symptoms of GERD regardless of the prokinetic type, refractoriness, and ethnicity. Additionally, treatment with PPI plus prokinetics for at least 4 weeks was found to be more beneficial than PPI monotherapy with respect to global symptom improvement. However, the QoL scores were not improved with PPI plus prokinetics treatment. Adverse events observed in response to PPI plus prokinetics treatment did not differ from those observed with PPI monotherapy. ConclusionsCombination of prokinetics with PPI treatment is more effective than PPI alone in GERD patients. Further high-quality trials with large sample sizes are needed to verify the effects based on prokinetic type.
#Gastroesophageal reflux #Gastrointestinal agents #Proton pump inhibitors

목차

등록된 정보가 없습니다.

참고문헌 (34)

참고문헌 신청
El-Serag HB / 2014 / Update on the epidemiology of gastro-oesophageal reflux disease : a systematic review / Gut 63:871~880 google schola Fass R / 2005 / Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next? / Aliment Pharmacol Ther 22:79~94 google schola Iwakiri K / 2016 / Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015 / J Gastroenterol 51:751~767 google schola 서호석 / 2018 / Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018 / Journal of Gastric Cancer 18(4):313~327 dbpia Sigterman KE / 2013 / Shortterm treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease / Cochrane Database Syst Rev :CD002095 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0